Lewis Connor, Gupta Akash, Gupta Neil K
Internal Medicine, Yale School of Medicine, New Haven, USA.
Internal Medicine, Yale New Haven Hospital, New Haven, USA.
Cureus. 2022 Jul 16;14(7):e26921. doi: 10.7759/cureus.26921. eCollection 2022 Jul.
Immunocompromised patients with COVID-19 can have prolonged disease courses that require escalation in care to inpatient or ICU settings. We report a case of a prolonged, active COVID-19 infection in an immunocompromised 61-year-old female with a history of non-Hodgkin's lymphoma. During her hospitalization, her cycle thresholds (CT) continued to worsen despite clinical improvement. We compared our patient's course and CTs to other reported cases in immunocompromised patients, investigating the efficacy of CTs and their use in evaluating disease progression and severity. RT-PCR tests targeting specific types of replicative viral RNA may have more utility in assessing disease severity and infectivity in immunocompromised patients. Our patient's disease course, similar to other reported cases, illustrates the need for improved treatment protocols and infection prevention for the immunocompromised population against SARS-CoV-2.
患有新冠肺炎的免疫功能低下患者可能会有病程延长的情况，这需要将护理级别提升至住院或重症监护病房。我们报告了一例61岁免疫功能低下女性的新冠肺炎长期活跃感染病例，该女性有非霍奇金淋巴瘤病史。在她住院期间，尽管临床症状有所改善，但她的循环阈值（CT）持续恶化。我们将我们患者的病程和CT值与其他免疫功能低下患者的报告病例进行了比较，研究了CT值在评估疾病进展和严重程度方面的有效性及其应用。针对特定类型复制性病毒RNA的逆转录聚合酶链反应（RT-PCR）检测在评估免疫功能低下患者的疾病严重程度和传染性方面可能更有用。我们患者的病程与其他报告病例相似，说明了针对免疫功能低下人群对抗严重急性呼吸综合征冠状病毒2（SARS-CoV-2）需要改进治疗方案和感染预防措施。
