阈值循环值能否正确反映 2019 年新型冠状病毒病（COVID-19）的严重程度？
Could threshold cycle value correctly reflect the severity of novel coronavirus disease 2019 (COVID-19)?
机构信息
Department of Clinical Infectious Diseases, Aichi Medical University Hospital, Aichi, Japan; Department of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
Department of Infection Control and Prevention, Aichi Medical University Hospital, Japan.
出版信息
J Infect Chemother. 2021 Jan;27(1):117-119. doi: 10.1016/j.jiac.2020.09.010. Epub 2020 Sep 9.
The novel coronavirus disease 2019 (COVID-19) is diagnosed by positive result of reverse transcription polymerase chain reaction (RT-PCR) for the novel coronavirus. We concluded that cycle threshold value (Ct-value) of real-time RT-PCR (rRT-PCR) assay could decrease as patients recover. Results of rRT-PCR assay could remain positive among asymptomatic patients for longer than 2 weeks. The discharge criteria of COVID-19 patients using a negative result of rRT-PCR should be reconsidered.
2019 年新型冠状病毒病（COVID-19）的诊断依据是新型冠状病毒逆转录聚合酶链反应（RT-PCR）的阳性结果。我们得出结论，实时 RT-PCR（rRT-PCR）检测的循环阈值（Ct 值）随着患者的康复而降低。无症状患者的 rRT-PCR 检测结果可在 2 周以上仍为阳性。使用 rRT-PCR 检测结果阴性作为 COVID-19 患者出院标准应重新考虑。
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