从（L.） Lippold 的果实中分离得到的三种新的强心苷及其细胞毒性活性。
Three new cardenolides from the fruits of (L.) Lippold and their cytotoxic activities.
机构信息
Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University, Dongguan, P.R. China.
Marine Biomedical Research Institute, The Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim, Guangdong Medical University, Zhanjiang, P.R. China.
出版信息
Nat Prod Res. 2024 Jan-Feb;38(2):211-219. doi: 10.1080/14786419.2022.2113876. Epub 2022 Aug 19.
Phytochemical investigations on the fruits of (L.) Lippold led to obtain three new cardenolides (-) and five known analogues (-). Their structures were elucidated by means of UV, IR, HR-ESI-MS, 1D and 2D NMR spectroscopic data analysis. Compounds and represent the first examples of naturally occurring cardenolides with 19--5(10)-ene group and --3-demethyl-thevetose, respectively. Compound is a rare CD-homocardenolide in nature. All isolated cardenolides (-) were evaluated for their cytotoxic activities against four human cancer cell lines (MCF-7, HCT-116, HeLa and HepG2), and the results indicated the compounds with sugar units (, , , and ) exhibited stronger cytotoxic activities with IC values ranging between 0.022 and 0.308 M.
植物化学研究表明，（L.） Lippold 的果实中含有三种新的卡烯内酯（-）和五种已知类似物（-）。通过 UV、IR、HR-ESI-MS、1D 和 2D NMR 光谱数据分析，确定了它们的结构。化合物和分别代表了自然界中首次出现的具有 19--5(10)-烯基和--3-去甲替维醇的天然卡烯内酯。化合物是一种罕见的天然 CD-同型卡烯内酯。所有分离得到的卡烯内酯（-）都对四种人癌细胞系（MCF-7、HCT-116、HeLa 和 HepG2）进行了细胞毒性活性评价，结果表明具有糖单元的化合物（、、、和）表现出更强的细胞毒性活性，IC 值范围在 0.022 到 0.308 μM 之间。
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