Instituto de Ciências Ambientais Químicas e Farmacêuticas, Universidade Federal de São Paulo, Unifesp, Diadema, SP, Brazil.
Therapeutics Research Centre, the University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia.
Curr Drug Deliv. 2023;20(9):1275-1287. doi: 10.2174/1567201819666220818162455.
Mosquito-borne diseases such as dengue, malaria, yellow fever, chikungunya and Zika virus affect millions of people worldwide each year. Vector control and personal protection are very important to minimize the spread of diseases, and the use of repellent is an economic practice to prevent them. The application of repellent, which acts on the skin to form a vapor layer with a repellent odor to mosquitos, is recommended as an economic prevention and practice. The natural botanical product Citronella is an effective mosquito repellent due to the high concentrations of active chemical constituents present, notably terpenic alcohols. However, citronella tends to evaporate quickly from the skin surface, resulting in a rapid loss of activity. Strategies to increase repellency time, while at the same time minimizing toxicity, are major focuses of research and development in natural repellent products. Here we highlight the role of extended-release systems (ERS) of citronella oil in this approach.
蚊媒传染病，如登革热、疟疾、黄热病、基孔肯雅热和寨卡病毒，每年在全球影响数百万人。病媒控制和个人防护对于最大限度地减少疾病传播非常重要，使用驱虫剂是一种经济的预防措施。驱虫剂的应用，通过在皮肤上形成一层具有驱虫气味的蒸气层来发挥作用，被推荐作为一种经济有效的预防和实践措施。天然植物产品香茅因其高浓度的活性化学物质而成为一种有效的驱蚊剂，特别是萜类醇。然而，香茅往往会从皮肤表面迅速蒸发，导致活性迅速丧失。提高驱蚊时间，同时最大限度地降低毒性，是天然驱蚊产品研发的重点。在这里，我们强调了香茅油的延长释放系统（ERS）在这方面的作用。
