Department of Radiology, The First Medical Center of PLA General Hospital, Beijing, China.
Department of Ultrasound, The Eighth Medical Center of PLA General Hospital, Beijing, China.
Medicine (Baltimore). 2022 Aug 19;101(33):e28659. doi: 10.1097/MD.0000000000028659.
3-dimention (3D) Cube isotropic volumetric magnetic resonance imaging (MRI) facilitates comprehensive recognition of microinfarcts while it takes long scanning time. HyperSense compressed sensing is an emerging technique for accelerating MRI acquisition to reduce scanning time, while its application along with 3D Cube MRI for microinfarcts is seldom reported. Therefore, this study aimed to investigate the efficiency of 3D Cube FLAIR plus HyperSense compressed sensing technique versus conventional 2-dimention (2D) FLAIR scanning in the detection of cortical microinfarcts (CMIs). Totally 59 patients with cerebrovascular disease were enrolled then scanned by 3D Cube FLAIR plus HyperSense compressed sensing and 2D T2WI FLAIR sequences. The image quality scores, signal-to-noise ratio (SNR) for gray matter (GM), SNR for white matter (WM), their contrast-to-noise ratio (WM-to-GM CNR), detected number of CMIs were evaluated. 3D Cube FLAIR plus HyperSense showed a dramatically increased scores of uniformity, artifact, degree of lesion displacement, and overall image quality compared to 2D T2WI FLAIR. Meanwhile, it exhibited similar SNRwm and SNRgm, but a higher WM-to-GM contrast-to-noise ratio compared with 2D T2WI FLAIR. Furthermore, the scanning time of 3D Cube FLAIR plus HyperSense and 2D T2WI FLAIR were both set as 2.5 minutes. Encouragingly, 244 CMIs were detected by 3D Cube FLAIR plus HyperSense, which was higher compared to 2D T2WI FLAIR (106 detected CMIs). 3D Cube FLAIR plus HyperSense compressed sensing is superior to 2D T2WI FLAIR scanning regarding image quality, spatial resolution, detection rate for CMIs; meanwhile, it does not increase the scanning time. These findings may contribute to early detection and treatment of stroke.
三维（3D）立方体各向同性容积磁共振成像（MRI）有助于全面识别微梗死，但其扫描时间较长。超感知压缩感知是一种新兴的加速 MRI 采集技术，可缩短扫描时间，但将其与 3D 立方体 MRI 用于微梗死的应用很少有报道。因此，本研究旨在探讨 3D 立方体 FLAIR 加超感知压缩感知技术与常规二维（2D）FLAIR 扫描在检测皮质微梗死（CMIs）中的效率。共纳入 59 例脑血管病患者，分别行 3D 立方体 FLAIR 加超感知压缩感知和 2D T2WI FLAIR 扫描。评估图像质量评分、灰质（GM）信噪比（SNR）、白质（WM）SNR、WM 与 GM 对比噪声比（WM-GM CNR）、检测到的 CMIs 数量。3D 立方体 FLAIR 加超感知在均匀性、伪影、病变移位程度和整体图像质量方面的评分均明显高于 2D T2WI FLAIR。同时，它表现出相似的 WM-SNR 和 GM-SNR，但与 2D T2WI FLAIR 相比，WM-GM 对比度噪声比更高。此外，3D 立方体 FLAIR 加超感知和 2D T2WI FLAIR 的扫描时间均设置为 2.5 分钟。令人鼓舞的是，3D 立方体 FLAIR 加超感知检测到 244 个 CMIs，高于 2D T2WI FLAIR（检测到 106 个 CMIs）。3D 立方体 FLAIR 加超感知在图像质量、空间分辨率、CMIs 检测率方面优于 2D T2WI FLAIR 扫描，同时不增加扫描时间。这些发现可能有助于早期发现和治疗中风。
