Drug hypersensitivity syndrome induced by sulfasalazine: A case report.

INTRODUCTION

Drug hypersensitivity syndrome (DHS) induced by sulfasalazine is a serious systemic delayed adverse drug reaction, which is associated with significant morbidity and mortality.

PATIENT CONCERNS

A 52-year-old man was hospitalized for developing a rash after 3 weeks of sulfasalazine treatment for ulcerative colitis (UC).

DIAGNOSIS

The patient was diagnosed with DHS based on his drug history, clinical manifestations, and laboratory test results.

INTERVENTIONS

The patient was administered intravenous glucocorticoids. The patient's condition improved after treatment with human immunoglobulin and antihistamines.

OUTCOMES

Combination therapy of glucocorticoid and gamma globulin, the whole-body pruritus disappeared, and no new rash appeared. The whole-body rash subsided or turned dark red.

CONCLUSION

This article describes the diagnosis and treatment process of a case of sulfasalazine-induced DHS and reviews the relevant literature to improve clinician understanding and avoid misdiagnosis and missed diagnosis.