Brandt J, Corwin J, Krafft L
Johns Hopkins University School of Medicine, Baltimore, MD.
J Clin Exp Neuropsychol. 1992 Sep;14(5):773-84. doi: 10.1080/01688639208402862.
Verbal recall and recognition were examined in Huntington's disease (HD) and Alzheimer's disease (AD) patients. Subgroups of HD and AD patients were matched for overall severity of dementia. Subjects were administered the Hopkins Verbal Learning Test, a list-learning task with three free-recall trials followed immediately by one yes/no recognition trial with semantically related and unrelated distractors. The matched AD and HD groups did not differ in the number of words recalled, although the HD patients showed slightly greater improvement over trials. Recognition performance was evaluated with measures of accuracy and response bias that are independent of each other. The matched groups did not differ in overall recognition accuracy, but the AD patients tended to have a more liberal ("yea-saying") response bias than did the HD patients. In addition, only the AD patients were differentially enticed to false-positive responding by semantically related distractors. The results suggest that the rule for making decisions when uncertain, rather than memory strength per se, distinguishes the recognition memory performance of AD and HD patients.
对亨廷顿舞蹈症（HD）患者和阿尔茨海默病（AD）患者进行了言语回忆和识别测试。HD患者亚组和AD患者亚组在痴呆症的总体严重程度上进行了匹配。受试者接受了霍普金斯言语学习测试，这是一项列表学习任务，包括三次自由回忆试验，随后立即进行一次是/否识别试验，其中包含语义相关和不相关的干扰项。匹配的AD组和HD组在回忆的单词数量上没有差异，尽管HD患者在试验中表现出稍大的进步。识别表现通过相互独立的准确性和反应偏差测量来评估。匹配组在总体识别准确性上没有差异，但AD患者比HD患者倾向于有更宽松的（“肯定回答”）反应偏差。此外，只有AD患者在语义相关干扰项的影响下更容易出现假阳性反应。结果表明，在不确定时做出决策的规则，而非记忆强度本身，区分了AD患者和HD患者的识别记忆表现。
