Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg 7505, Cape Town, South Africa.
Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg 7505, Cape Town, South Africa; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Stellenbosch University, Cape Town, South Africa.
Child Abuse Negl. 2022 Nov;133:105831. doi: 10.1016/j.chiabu.2022.105831. Epub 2022 Aug 17.
Childhood maltreatment leads to lifelong health risks, particularly in women. Although reproductive health has been linked to such maltreatment, limited literature exists on its association with polycystic ovary syndrome (PCOS).
In a sample of psychiatrically healthy women, we evaluated the impact of child maltreatment (subtypes of abuse and neglect) on women's reproductive health outcomes, specifically PCOS.
The 237 psychiatrically healthy women, aged between 18 and 79 years, were control participants in a case-control study (SHARED ROOTS), conducted in Cape Town, South Africa, between May 2014 and June 2017.
Probable PCOS was based on a history of symptoms of ovulatory dysfunction and hyperandrogenism or a diagnosis of PCOS. We conducted hierarchical logistic regression models to assess which child maltreatment subtypes (emotional, physical and sexual abuse and emotional and physical neglect) were significantly associated with PCOS, controlling for sociodemographic and clinical factors.
Probable PCOS was present in 29 (12.2 %) women. Emotional abuse (31.6 %) was the most frequent type of child maltreatment and was significantly associated with PCOS (OR = 5.11, CI 1.87; 13.98), including when other maltreatment types were accounted for (OR = 3.90, CI 1.27; 12.02). Physical abuse was associated with PCOS (OR = 4.21, CI 1.43; 12.38), but was not significant when other maltreatment types were factored in.
Child maltreatment is independently associated with PCOS in women without psychiatric disorders. In the context of all maltreatment subtypes, emotional abuse remained associated with PCOS, suggesting its unique effect on this endocrinopathy.
儿童期虐待会导致终生健康风险，尤其是在女性中。尽管生殖健康与这种虐待有关，但关于其与多囊卵巢综合征（PCOS）的关联的文献有限。
在一组精神健康的女性中，我们评估了儿童虐待（虐待和忽视的亚型）对女性生殖健康结果，特别是 PCOS 的影响。
237 名年龄在 18 至 79 岁之间的精神健康女性是南非开普敦 SHARED ROOTS 病例对照研究的对照组参与者，该研究于 2014 年 5 月至 2017 年 6 月进行。
可能的 PCOS 基于排卵功能障碍和高雄激素血症的症状史或 PCOS 的诊断。我们进行了层次逻辑回归模型，以评估哪种儿童虐待亚型（情感、身体和性虐待以及情感和身体忽视）与 PCOS 显著相关，同时控制了社会人口统计学和临床因素。
29 名（12.2%）女性存在可能的 PCOS。情感虐待（31.6%）是最常见的儿童虐待类型，与 PCOS 显著相关（OR=5.11，CI 1.87；13.98），包括在考虑其他虐待类型时（OR=3.90，CI 1.27；12.02）。身体虐待与 PCOS 相关（OR=4.21，CI 1.43；12.38），但在考虑其他虐待类型时并不显著。
在没有精神障碍的女性中，儿童虐待与 PCOS 独立相关。在所有虐待亚型的背景下，情感虐待仍然与 PCOS 相关，表明其对这种内分泌疾病的独特影响。
