Department of Veterinary Sciences, University of Turin, Largo Braccini 2, 10095 Grugliasco, TO, Italy.
Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole 10, 10043 Orbassano, TO, Italy.
Int J Mol Sci. 2021 Aug 28;22(17):9358. doi: 10.3390/ijms22179358.
Plasticity, and in particular, neurogenesis, is a promising target to treat and prevent a wide variety of diseases (e.g., epilepsy, stroke, dementia). There are different types of plasticity, which vary with age, brain region, and species. These observations stress the importance of defining plasticity along temporal and spatial dimensions. We review recent studies focused on brain plasticity across the lifespan and in different species. One main theme to emerge from this work is that plasticity declines with age but that we have yet to map these different forms of plasticity across species. As part of this effort, we discuss our recent progress aimed to identify corresponding ages across species, and how this information can be used to map temporal variation in plasticity from model systems to humans.
可塑性，尤其是神经发生，是治疗和预防多种疾病（如癫痫、中风、痴呆）的有前途的靶点。有不同类型的可塑性，其随年龄、脑区和物种而变化。这些观察结果强调了沿着时间和空间维度定义可塑性的重要性。我们回顾了最近的研究，这些研究集中在整个生命周期和不同物种中的大脑可塑性。这项工作的一个主要主题是，随着年龄的增长，可塑性会下降，但我们还没有在不同物种中绘制出这些不同形式的可塑性。作为这项工作的一部分，我们讨论了我们最近的进展，旨在确定跨物种的对应年龄，以及如何将这些信息从模型系统映射到人类的可塑性的时间变化。
