植物抗癌剂XLIV. 裂叶星蕨中的细胞毒性成分。

Plant anticancer agents XLIV. Cytotoxic constituents from Stizophyllum riparium.

作者信息

Duh C Y, Pezzuto J M, Kinghorn A D, Leung S L, Farnsworth N R

出版信息

J Nat Prod. 1987 Jan-Feb;50(1):63-74. doi: 10.1021/np50049a010.

Abstract

Bioactivity-guided fractionation of a CHCl3 extract of Stizophyllum riparium has afforded six new compounds, namely, the triterpene esters, 3 beta-hydroxy-24-transferulyloxyurs-12-en-28-oic acid, 3 beta-hydroxy-24-cis-ferulyloxyurs-12-en-28-oic acid, 3 beta, 19-dihydroxy-24-trans-ferulyloxyurs-12-en-28-oic acid, and the pregnane derivatives, 2 alpha, 3 beta, 12 beta-trihydroxypregna-4,7,16-trien-20-one, 2 alpha, 3 beta, 12 beta-trihydroxypregna-4,7-dien-20-one, and 16 alpha-methoxy-2 alpha, 3 beta, 12 beta-trihydroxypregna-4,7-dien-20-one. The structures of these isolates were established by spectroscopic and chemical methods. Compounds 1, 2, and 4 exhibited cytotoxic activity against the P-388 lymphocytic leukemia test system in cell culture.

摘要

对裂叶耳蕨氯仿提取物进行生物活性导向分离，得到了6个新化合物，即三萜酯类化合物3β-羟基-24-阿魏酰氧基乌苏-12-烯-28-酸、3β-羟基-24-顺式阿魏酰氧基乌苏-12-烯-28-酸、3β,19-二羟基-24-反式阿魏酰氧基乌苏-12-烯-28-酸，以及孕烷衍生物2α,3β,12β-三羟基孕甾-4,7,16-三烯-20-酮、2α,3β,12β-三羟基孕甾-4,7-二烯-20-酮和16α-甲氧基-2α,3β,12β-三羟基孕甾-4,7-二烯-20-酮。这些分离物的结构通过光谱和化学方法确定。化合物1、2和4在细胞培养中对P-388淋巴细胞白血病测试系统表现出细胞毒性活性。