植物抗癌剂XXXIX：密苏里鸢尾（鸢尾科）中的三萜类化合物

Plant anticancer agents XXXIX: Triterpenes from Iris missouriensis (Iridaceae).

作者信息

Wong S M, Oshima Y, Pezzuto J M, Fong H H, Farnsworth N R

出版信息

J Pharm Sci. 1986 Mar;75(3):317-20. doi: 10.1002/jps.2600750324.

Abstract

Employing the roots of Iris missouriensis, two known triterpenes, iso-iridogermanal and zeorin, were isolated and identified. As presently reported, they were found to demonstrate cytotoxic activity toward cultured P-388 cells (ED50 = 0.1 and 1.1 microgram/mL, respectively). Additionally, a new triterpene that demonstrated an ED50 of 8.5 micrograms/mL was isolated. On the basis of spectral analysis and chemical correlation with zeorin, the structure was shown to be 6 6 alpha-hydroxy-A'-neogermmacer-22(29)-en-30-oic acid (missourin).

摘要

利用密苏里鸢尾的根，分离并鉴定出两种已知的三萜类化合物，异鸢尾醛和玉米苷。如目前所报道的，发现它们对培养的P - 388细胞具有细胞毒性活性（ED50分别为0.1和1.1微克/毫升）。此外，还分离出一种新的三萜类化合物，其ED50为8.5微克/毫升。基于光谱分析以及与玉米苷的化学关联，其结构被确定为6 6α - 羟基 - A' - 新格玛烯 - 22(29) - 烯 - 30 - 酸（密苏里苷）。