Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran.
Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
J Cardiothorac Surg. 2022 Aug 19;17(1):185. doi: 10.1186/s13019-022-01932-5.
Infective endocarditis (IE) is a severe disease that is still associated with high mortality despite recent advances in diagnosis and treatment. HACEK organisms (Haemophilus spp., Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae) are gram-negative bacteria that are part of the normal flora of the mouth and upper respiratory tract in humans. These organisms cause a wide range of infections, of which IE is one of the most notable. In order to control and prevent endocarditis caused by HACEK, measures such as oral hygiene and the use of prophylactic drugs should be used for people at risk, including people with underlying heart disease and people with artificial valves. This review is a summary of the main aspects of IE focusing on HACEK organisms.
感染性心内膜炎（IE）是一种严重的疾病，尽管近年来在诊断和治疗方面取得了进展，但仍与高死亡率相关。HACEK 病原体（嗜血杆菌属、伴放线放线杆菌、心杆菌属、侵蚀艾肯菌和金氏金杆菌）是革兰氏阴性菌，是人类口腔和上呼吸道正常菌群的一部分。这些生物体引起广泛的感染，其中 IE 是最显著的一种。为了控制和预防 HACEK 引起的心内膜炎，应针对高危人群采取口腔卫生和预防性药物等措施，包括患有基础心脏病和人工瓣膜的人群。本综述总结了 IE 的主要方面，重点介绍了 HACEK 病原体。
