Salave Sagar, Prayag Kedar, Rana Dhwani, Amate Prakash, Pardhe Rupali, Jadhav Ajinkya, Jindal Anil B, Benival Derajram
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, India.
Department of Pharmacy, Birla Institute of Technology and Science Pilani (BITS PILANI), Pilani, Rajasthan, India.
Recent Adv Drug Deliv Formul. 2022;16(3):170-191. doi: 10.2174/2667387816666220819124605.
The Hot Melt Extrusion (HME) technique has shown tremendous potential in transforming highly hydrophobic crystalline drug substances into amorphous solids without using solvents. This review explores in detail the general considerations involved in the process of HME, its applications and advances.
The present review examines the physicochemical properties of polymers pertinent to the HME process. Theoretical approaches for the screening of polymers are highlighted as a part of successful HME processed drug products. The critical quality attributes associated with the process of HME are also discussed in this review. HME plays a significant role in the dosage form design, and the same has been mentioned with suitable examples. The role of HME in developing several sustained release formulations, films, and implants is described along with the research carried out in a similar domain.
The method includes the collection of data from different search engines like PubMed, ScienceDirect, and SciFinder to get coverage of relevant literature for accumulating appropriate information regarding HME, its importance in pharmaceutical product development, and advanced applications.
HME is known to have advanced pharmaceutical applications in the domains related to 3D printing, nanotechnology, and PAT technology. HME-based technologies explored using Design-of- Experiments also lead to the systematic development of pharmaceutical formulations.
HME remains an adaptable and differentiated technique for overall formulation development.
热熔挤出（HME）技术在不使用溶剂的情况下将高度疏水的结晶药物转化为无定形固体方面显示出巨大潜力。本综述详细探讨了HME过程中涉及的一般考虑因素、其应用和进展。
本综述研究了与HME过程相关的聚合物的物理化学性质。作为成功的HME加工药品的一部分，突出了聚合物筛选的理论方法。本综述还讨论了与HME过程相关的关键质量属性。HME在剂型设计中起着重要作用，并通过合适的例子进行了说明。描述了HME在开发几种缓释制剂、薄膜和植入物中的作用以及在类似领域开展的研究。
该方法包括从不同的搜索引擎如PubMed、ScienceDirect和SciFinder收集数据，以涵盖相关文献，积累有关HME及其在药品开发中的重要性和先进应用的适当信息。
已知HME在与3D打印、纳米技术和PAT技术相关的领域具有先进的药物应用。使用实验设计探索的基于HME的技术也导致了药物制剂的系统开发。
HME仍然是整体制剂开发中一种适应性强且有区别的技术。
