Tan Lina, Huan Ren, Wu Li Fang, Bao Yanni, Ma Yu Chen, Zou Qian Li, Yong Jin
School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.
Mini Rev Med Chem. 2023;23(4):399-411. doi: 10.2174/1389557522666220819103907.
The self-assembly behavior of polypeptides is common in nature. Compared with monopeptides, polypeptide-based self-assembled nanomaterials with ordered structures have good thermal stability, mechanical stability, semi-conductivity, piezoelectric and optical properties. In recent years, the self-assembly of polypeptides has become a hot topic in the material science and biomedical field. By reasonably adjusting the molecular structure of the polypeptide and changing the external environment of the polypeptide, the polypeptide can be self-assembled or triggered by non-covalent bonding forces such as hydrogen bond, hydrophobicity, and π - π accumulation to form specific polypeptide assemblies such as nanoparticles, hydrogels, nanofibers, and micelles. Due to good biocompatibility and controllable degradability, polypeptide-based self-assembled nanomaterials have been widely used in the fields of nanotechnology, imaging technology, biosensor, and biomedical science. As a new drug delivery system, the polypeptide-drug conjugate has the advantages of low toxicity, high efficiency, enhanced drug stability, and avoiding side effects. This paper reviews the research progress of polypeptide-drug self-assembly nanostructure in recent years. Several structural models of polypeptide self-assembly technology and the mechanism of polypeptide self-assembly are introduced. Then the assembly form of polypeptide-drug self-assembly and the application of selfassembly compound therapy is described.
多肽的自组装行为在自然界中很常见。与单肽相比，具有有序结构的基于多肽的自组装纳米材料具有良好的热稳定性、机械稳定性、半导电性、压电性和光学性质。近年来，多肽的自组装已成为材料科学和生物医学领域的一个热门话题。通过合理调整多肽的分子结构并改变多肽的外部环境，多肽可以通过氢键、疏水性和π-π堆积等非共价键力进行自组装或被触发，形成特定的多肽组装体，如纳米颗粒、水凝胶、纳米纤维和胶束。由于具有良好的生物相容性和可控的降解性，基于多肽的自组装纳米材料已广泛应用于纳米技术、成像技术、生物传感器和生物医学科学领域。作为一种新型药物递送系统，多肽-药物缀合物具有低毒、高效、增强药物稳定性和避免副作用等优点。本文综述了近年来多肽-药物自组装纳米结构的研究进展。介绍了多肽自组装技术的几种结构模型以及多肽自组装的机制。然后描述了多肽-药物自组装的组装形式以及自组装复合疗法的应用。
