Wang Yue, Ding Xiufang, Zhang Sida, Zhang Ruihua, Chen Dong, Xu Jianfu, Chen Long
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
State Key Laboratory of Nuclear Biological Chemical Protection for Civilian, Beijing 102205, China.
Sheng Wu Gong Cheng Xue Bao. 2023 Jan 25;39(1):177-191. doi: 10.13345/j.cjb.220335.
Self-assembly refers to the spontaneous process where basic units such as molecules and nanostructured materials form a stable and compact structure. Peptides can self-assemble by non-covalent driving forces to form various morphologies such as nanofibers, nano layered structures, and micelles. Peptide self-assembly technology has become a hot research topic in recent years due to the advantages of definite amino acid sequences, easy synthesis and design of peptides. It has been shown that the self-assembly design of certain peptide drugs or the use of self-assembled peptide materials as carriers for drug delivery can solve the problems such as short half-life, poor water solubility and poor penetration due to physiological barrier. This review summarizes the formation mechanism of self-assembled peptides, self-assembly morphology, influencing factors, self-assembly design methods and major applications in biomedical field, providing a reference for the efficient use of peptides.
自组装是指分子和纳米结构材料等基本单元形成稳定且紧密结构的自发过程。肽可以通过非共价驱动力进行自组装，形成各种形态，如纳米纤维、纳米层状结构和胶束。由于氨基酸序列明确、肽易于合成和设计等优点，肽自组装技术近年来已成为一个热门的研究课题。研究表明，某些肽药物的自组装设计或使用自组装肽材料作为药物递送载体，可以解决诸如半衰期短、水溶性差以及因生理屏障导致的穿透性差等问题。本文综述了自组装肽的形成机制、自组装形态、影响因素、自组装设计方法及其在生物医学领域的主要应用，为肽的高效利用提供参考。
