Shapiro K, Kohn I J, Takei F, Zee C
J Neurosurg. 1987 Jul;67(1):88-92. doi: 10.3171/jns.1987.67.1.0088.
Intracranial pressure (ICP) was measured simultaneously at multiple sites in cats to determine if transmantle pressure gradients were present in progressive hydrocephalus. The cats underwent craniectomy and intracisternal injection of kaolin; 4 to 9 weeks later ICP was measured at the ventricle, cisterna magna, and convexity subarachnoid space, and in the brain tissue and the sagittal sinus. In 13 cats in which ventricular size conformed to previously established norms for duration of hydrocephalus, there were no demonstrable gradients of pressure at any of the sites of measurement according to one-way analysis of variance (p greater than 0.05). The mean (+/- standard error of the mean) peak and trough pressures (in mm Hg) at each site were: ventricle, 12.7 +/- 0.7 and 12.0 +/- 0.6; cisterna magna, 12.9 +/- 0.8 and 12.3 +/- 0.7; subarachnoid space, 12.7 +/- 0.8 and 12.1 +/- 0.7; brain tissue, 12.9 +/- 0.9 and 12.4 +/- 0.9; and sagittal sinus, 13.1 +/- 0.8 and 11.9 +/- 0.8. These results indicate that ventricular expansion can progress without measurable transmantle pressure gradients.
在猫的多个部位同时测量颅内压（ICP），以确定在进行性脑积水时是否存在跨脑压梯度。这些猫接受了颅骨切除术并向脑池内注射高岭土；4至9周后，在脑室、枕大池、蛛网膜下腔凸面以及脑组织和矢状窦测量ICP。在13只脑室大小符合先前确立的脑积水持续时间标准的猫中，根据单向方差分析，在任何测量部位均未发现明显的压力梯度（p大于0.05）。每个部位的平均（±平均标准误差）峰值和谷值压力（以毫米汞柱为单位）分别为：脑室，12.7±0.7和12.0±0.6；枕大池，12.9±0.8和12.3±0.7；蛛网膜下腔，12.7±0.8和12.1±0.7；脑组织，12.9±0.9和12.4±0.9；矢状窦，13.1±0.8和11.9±0.8。这些结果表明，脑室扩张可以在没有可测量的跨脑压梯度的情况下进展。
