Haug A, Høstmark A T
J Nutr. 1987 Jun;117(6):1011-7. doi: 10.1093/jn/117.6.1011.
The effect of fish oil and coconut oil on plasma lipoproteins and lipoprotein-catabolizing enzymes [lipoprotein lipase (LPL) and hepatic endothelial lipase (HL)] was studied in rats. Male rats were fed for 4 wk purified diets containing equienergetic, amounts of either coconut oil (group A), coconut oil:fish oil, 50:50 (group B) or fish oil (group C). Whole plasma triacylglycerol, cholesterol and phospholipid concentrations were appreciably lower in group C than in group A, mainly due to a fall in very low density lipoprotein (VLDL) and subgroup 2 of high density lipoprotein (HDL2), with less consistent changes in LDL and HDL3. VLDL components of group B were also considerably lower than corresponding ones in group A. LPL and HL activities were about 50% lower in groups B and C than in group A. Increased hepatic triacylglycerol and cholesterol concentrations were observed in groups B and C. It is suggested that the decrease in LPL and HL activity of fish oil-fed rats may be an adaptive response to the low concentration of the substrate (triacylglycerols) for these enzymes.
在大鼠中研究了鱼油和椰子油对血浆脂蛋白及脂蛋白分解代谢酶[脂蛋白脂肪酶（LPL）和肝内皮脂肪酶（HL）]的影响。雄性大鼠喂食4周含等量能量的纯化日粮，日粮分别含椰子油（A组）、椰子油：鱼油为50:50（B组）或鱼油（C组）。C组的全血浆三酰甘油、胆固醇和磷脂浓度明显低于A组，主要是由于极低密度脂蛋白（VLDL）和高密度脂蛋白2亚组（HDL2）降低，而低密度脂蛋白（LDL）和高密度脂蛋白3（HDL3）变化不太一致。B组的VLDL成分也明显低于A组相应成分。B组和C组的LPL和HL活性比A组低约50%。B组和C组肝脏三酰甘油和胆固醇浓度升高。提示喂食鱼油的大鼠LPL和HL活性降低可能是对这些酶底物（三酰甘油）低浓度的一种适应性反应。
