Vecera Rostislav, Orolin Jan, Skottová Nina, Kazdová Ludmila, Oliyarnik Olena, Ulrichová Jitka, Simánek Vilím
Institute of Pharmacology, Medical Faculty, Palacký University, Hnevotínská 3, 775 15, Olomouc, Czech Republic.
Plant Foods Hum Nutr. 2007 Jun;62(2):59-63. doi: 10.1007/s11130-007-0042-z.
This work focused on the effect of Maca on lipid, anti-oxidative, and glucose parameters in hereditary hypertriglyceridemic (HHTg) rat. Maca (1%) was administred to rats as a part of a high-sucrose diet (HSD) for 2 weeks. Rosiglitazone (0.02%) was used as a positive control. Maca significantly decreased the levels of VLDL (very low density lipoproteins), LDL (low density lipoproteins), and total cholesterol, and also the level of TAG (triacylglycerols) in the plasma, VLDL, and liver. Maca, as well as rosiglitazone, significantly improved glucose tolerance, as the decrease of AUC (area under the curve) of glucose showed, and lowered levels of glucose in blood. The activity of SOD (superoxide dismutase) in the liver, the GPX (glutathione peroxidase) in the blood, and the level of GSH (glutathione) in liver increased in all cases significantly. Results demonstrate that maca seems to be promising for a positive influence on chronic human diseases (characterized by atherogenous lipoprotein profile, aggravated antioxidative status, and impaired glucose tolerance), and their prevention.
这项研究聚焦于玛咖对遗传性高甘油三酯血症（HHTg）大鼠的脂质、抗氧化和血糖参数的影响。将1%的玛咖作为高蔗糖饮食（HSD）的一部分给予大鼠，持续2周。罗格列酮（0.02%）用作阳性对照。玛咖显著降低了血浆、极低密度脂蛋白（VLDL）和肝脏中极低密度脂蛋白、低密度脂蛋白（LDL）以及总胆固醇的水平，还有甘油三酯（TAG）的水平。玛咖以及罗格列酮显著改善了葡萄糖耐量，正如葡萄糖曲线下面积（AUC）的降低所示，并且降低了血液中的葡萄糖水平。在所有情况下，肝脏中超氧化物歧化酶（SOD）的活性、血液中谷胱甘肽过氧化物酶（GPX）的活性以及肝脏中谷胱甘肽（GSH）的水平均显著增加。结果表明，玛咖似乎有望对慢性人类疾病（其特征为致动脉粥样硬化脂蛋白谱、抗氧化状态恶化和葡萄糖耐量受损）及其预防产生积极影响。
