Romsos D R, Vander Tuig J G, Kerner J, Grogan C K
J Nutr. 1987 Jun;117(6):1121-8. doi: 10.1093/jn/117.6.1121.
Rats with obesity-producing, hypothalamic knife cuts (KC) were fed a purified high fat diet for 9 wk. KC rats consumed more energy (+70-100%) and retained energy with a much higher efficiency than control rats. Adrenalectomy of KC rats 1 wk (before gross obesity was evident) or 5 wk (when KC rats were 70% overweight) after KC surgery caused a reduction in energy intake to levels approximating those of control rats. Furthermore, energy retention in adrenalectomized KC rats was depressed more than could be explained on the basis of the reduction in energy intake. Two factors associated with the reduction in energy retention, urinary excretion of norepinephrine, an indicator of sympathetic nervous system activity, and GDP binding to brown adipose tissue mitochondria, an indicator of the thermogenic capacity of the tissue, were higher in vadrenalectomized KC rats than in pair-fed KC rats. Removal of the adrenals not only suppressed hyperphagia in KC rats fed a high fat diet, but also increased energy expenditure per kilocalorie consumed.
对患有肥胖症的下丘脑切断术（KC）大鼠喂食纯化的高脂饮食9周。KC大鼠比对照大鼠消耗更多能量（增加70 - 100%），且能量留存效率高得多。在KC手术后1周（明显肥胖之前）或5周（KC大鼠超重70%时）对KC大鼠进行肾上腺切除术，导致能量摄入减少至接近对照大鼠的水平。此外，肾上腺切除的KC大鼠的能量留存减少幅度超过了能量摄入减少所能解释的范围。与能量留存减少相关的两个因素，即去甲肾上腺素的尿排泄（交感神经系统活动的指标）和GDP与棕色脂肪组织线粒体的结合（该组织产热能力的指标），在肾上腺切除的KC大鼠中比配对喂食的KC大鼠中更高。切除肾上腺不仅抑制了喂食高脂饮食的KC大鼠的食欲亢进，还增加了每消耗千卡的能量消耗。
