Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Clinical Informationist Research Group, Health Information Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
BMC Gastroenterol. 2022 Aug 20;22(1):393. doi: 10.1186/s12876-022-02460-1.
Covid-19 is a pandemic disease that is more severe and mortal in people with immunodeficiency, such as those with inflammatory bowel disease (IBD). On the other hand, no definitive treatment has been identified for it and the best way to control it is wide spread vaccination. The aim of this study was to evaluate the benefits and side effects of different vaccines in patients with IBD. Three Electronic databases [Medline (accessed from PubMed), Scopus, Science Direct, and Cochrane] were searched systematically without time limit, using MESH terms and the related keywords in English language. We focused on the research studies on the effect and side effects of Covid-19 vaccination in patients with IBD. Articles were excluded if they were not relevant, or were performed on other patients excerpt patients with IBD. Considering the titles and abstracts, unrelated studies were excluded. The full texts of the remained studies were evaluated by authors, independently. Then, the studies' findings were assessed and reported. Finally, after reading the full text of the remained articles, 15 ones included in data extraction. All included studied were research study, and most of them (12/15) had prospective design. Totally, 8/15 studies were performed in single-center settings. In 8/15 studies, patients with IBD were compared with a control group. The results were summarized the in two categories: (1) the effect of vaccination, and (2) side effects. The effect of vaccination were assessed in 13/15 studies. Side effects of Covid-19 vaccination in patients with IBD were reported in 7/15 studies. Patients with IBD can be advised that vaccination may have limited minor side effects, but it can protect them from the serious complications of Covid-19 and its resulting mortality with a high success rate. They should be also mentioned in booster doses.
Covid-19 是一种在免疫功能低下人群中更为严重和致命的疾病，如炎症性肠病（IBD）患者。另一方面，目前尚未确定针对该疾病的明确治疗方法，控制该疾病的最佳方法是广泛接种疫苗。本研究旨在评估不同疫苗在 IBD 患者中的益处和副作用。我们系统地搜索了三个电子数据库[Medline（从 PubMed 访问）、Scopus、Science Direct 和 Cochrane]，没有时间限制，使用了英语的 MESH 术语和相关关键字。我们专注于研究 IBD 患者接种 Covid-19 疫苗的效果和副作用的研究。如果文章不相关或针对除 IBD 患者以外的其他患者进行，则将其排除在外。根据标题和摘要，排除了不相关的研究。作者独立评估了其余研究的全文。然后评估和报告了研究的结果。最后，在阅读了其余文章的全文后，有 15 篇文章被纳入数据提取。所有纳入的研究均为研究性研究，其中大多数（12/15）具有前瞻性设计。总共，8/15 项研究在单中心环境中进行。在 8/15 项研究中，将 IBD 患者与对照组进行了比较。结果总结为两类：（1）疫苗接种的效果，（2）副作用。在 13/15 项研究中评估了疫苗接种的效果。在 7/15 项研究中报告了 IBD 患者接种 Covid-19 疫苗的副作用。可以建议 IBD 患者接种疫苗可能会产生轻微的副作用，但可以保护他们免受 Covid-19 的严重并发症及其导致的高死亡率的影响。还应提及加强剂量。
