Molla Meseret Derbew, Bekele Abebe, Melka Daniel Seifu, Teklemariam Maria Degef, Challa Feyissa, Ayelign Birhanu, Shibabaw Tewodros, Akalu Yonas, Geto Zeleke
Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Int J Gen Med. 2021 Apr 20;14:1437-1447. doi: 10.2147/IJGM.S308158. eCollection 2021.
Hyperuricemia is related not only to an increased risk of gouty arthritis but also to an increased risk of cardiovascular diseases, resistant hypertension, insulin resistance and progression of type 2 diabetes mellitus. However, to the best of our knowledge, the prevalence of hyperuricemia and its associated factors have rarely been assessed in Ethiopian populations. Therefore, this study aimed to determine the prevalence of hyperuricemia and its associated factors among adult staff members of the Ethiopian Public Health Institute.
An institution-based cross-sectional study was conducted from July 1 to October 28, 2018. A total of 402 study participants were selected using a simple random sampling technique. An interviewer-administered questionnaire was used to collect the data. A blood sample of approximately 5 mL was collected from each study participant after overnight fasting through standardized methods for biochemical tests, and analyses were carried out with an automated COBAS 6000 analyzer. Data analysis was performed by SPSS version 20 software. The factors associated with the outcome variable were identified by bivariable and multivariable logistic regression analyses, and a value <0.05 was used to declare statistical significance.
The mean age of the study participants was 37.13±10.5 (mean ± SD), and 51.5% of the participants were male. The overall prevalence of hyperuricemia (>5.7 mg/dL for females and >7 mg/dL for males) was found to be 31.0%. The multivariable logistic analysis revealed that age (AOR=1.59, 95% CI 1.01-2.78), sex (AOR=1.66, 95% CI 1.02-2.70), cigarette smoking (AOR=2.05, 95% CI 1.01-4.19) and serum low-density lipoprotein (LDL) (AOR=1.70, 95% CI 1.01-2.87) were significantly associated with hyperuricemia.
The prevalence of hyperuricemia was relatively high compared to similar studies. Early screening for hyperuricemia in the general population, especially in those who are smokers, of older age and with high serum LDL levels, is vital to control its adverse effects at an early stage.
高尿酸血症不仅与痛风性关节炎风险增加有关，还与心血管疾病、难治性高血压、胰岛素抵抗及2型糖尿病进展风险增加有关。然而，据我们所知，埃塞俄比亚人群中高尿酸血症的患病率及其相关因素鲜有评估。因此，本研究旨在确定埃塞俄比亚公共卫生研究所成年工作人员中高尿酸血症的患病率及其相关因素。
2018年7月1日至10月28日进行了一项基于机构的横断面研究。采用简单随机抽样技术共选取402名研究参与者。通过访谈式问卷收集数据。每位研究参与者在过夜禁食后，通过标准化方法采集约5mL血液样本用于生化检测，并使用自动COBAS 6000分析仪进行分析。数据分析使用SPSS 20版软件。通过双变量和多变量逻辑回归分析确定与结局变量相关的因素，P值<0.05表示具有统计学意义。
研究参与者的平均年龄为37.13±10.5（均值±标准差），51.5%的参与者为男性。高尿酸血症（女性>5.7mg/dL，男性>7mg/dL）的总体患病率为31.0%。多变量逻辑分析显示，年龄（比值比[AOR]=1.59，95%置信区间[CI] 1.01 - 2.78）、性别（AOR=1.66，95% CI 1.02 - 2.70）、吸烟（AOR=2.05，95% CI 1.01 - 4.19）和血清低密度脂蛋白（LDL）（AOR=1.70，95% CI 1.01 - 2.87）与高尿酸血症显著相关。
与类似研究相比，高尿酸血症的患病率相对较高。对普通人群，尤其是吸烟者、老年人和血清LDL水平高的人群进行高尿酸血症的早期筛查，对于早期控制其不良影响至关重要。
