Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Stem Cell Res Ther. 2022 Aug 20;13(1):431. doi: 10.1186/s13287-022-03130-5.
Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically linked OoCs. Herein, the major innovations in their BoC system are discussed, followed by our future perspectives on enhancing the physiological relevance and scalability of BoCs for applications in studying disease mechanisms, testing potential therapeutics, and developing personalized medicine.
器官芯片（Organs-on-Chips，OoCs）平台由多个器官芯片组成，以重现不同组织之间的相互作用。最近，Vunjak-Novakovic 及其同事报道了一种由四个液流连接的器官芯片组成的器官芯片系统的创建。本文讨论了他们的器官芯片系统的主要创新点，并对如何提高器官芯片的生理相关性和可扩展性，以应用于研究疾病机制、测试潜在治疗方法和开发个性化药物提出了未来展望。
