Ma Yuqi, Sun Xiaoyi, Cai Ziwei, Tu Mengjing, Wang Yugang, Ouyang Qi, Yan Xueqing, Jing Gaoshan, Yang Gen
State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University, Beijing, 100871, China.
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 352001, China.
Mater Today Bio. 2024 Nov 29;29:101373. doi: 10.1016/j.mtbio.2024.101373. eCollection 2024 Dec.
The field of microfluidics has experienced rapid growth in the last several decades, yet it isn't considered to be a large industry comparable to semiconductor and consumer electronics. In this review, we analyzed the entire process of the transformation from research findings to commercialized products in microfluidics, as well as the significant gap during the whole developing process between microchip fabrication in R&D and large-scale production in the industry. We elaborated in detail on various materials in the microfluidics industry, including silicon, glass, PDMS, and thermoplastics, discussing their characteristics, production processes, and existing products. Despite challenges hindering the large-scale commercialization of microfluidic chips, ongoing advancements and applications are expected to integrate microfluidic technology into everyday life, transforming it into a commercially viable field with substantial potential and promising prospects.
在过去几十年里，微流控领域经历了快速发展，然而它并不被视为一个可与半导体和消费电子相媲美的大型产业。在本综述中，我们分析了微流控领域从研究成果到商业化产品的整个转化过程，以及在整个开发过程中研发阶段的微芯片制造与工业大规模生产之间的巨大差距。我们详细阐述了微流控行业中的各种材料，包括硅、玻璃、聚二甲基硅氧烷（PDMS）和热塑性塑料，讨论了它们的特性、生产工艺和现有产品。尽管存在阻碍微流控芯片大规模商业化的挑战，但持续的进步和应用有望将微流控技术融入日常生活，使其成为一个具有巨大潜力和广阔前景的商业可行领域。
