在具有中等心血管风险的人群中，身体活动与血管老化的关联：MARK 研究。按性别分析。

Association of physical activity with vascular aging in a population with intermediate cardiovascular risk, analysis by sex: MARK study.

机构信息

Primary Care Research Unit of Salamanca (APISAL), Biomedical Research Institute of Salamanca (IBSAL), Avenida de Portugal 83, 37005, Salamanca, Spain.

Health Service of Castilla and Leon (SACyL), Avenida de Portugal 83, 37005, Salamanca, Spain.

出版信息

Biol Sex Differ. 2022 Aug 20;13(1):46. doi: 10.1186/s13293-022-00456-w.

DOI:10.1186/s13293-022-00456-w

PMID:35987700

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9392339/

Abstract

BACKGROUND

The aim of this study was to analyze the association of physical activity and its intensity with arterial stiffness and vascular aging and differences by sex in a Spanish population with intermediate cardiovascular risk.

METHODS

Cross-sectional study. A total of 2475 individuals aged 35-75 years participated in the study. Brachial-ankle pulse wave velocity (baPWV) was measured using a VaSera VS-1500 device. Based on the age and sex percentile presented by the participants, the latter were classified as follows: those with a percentile above 90 and presenting established cardiovascular disease were classified as early vascular aging (EVA); those with a percentile between 10 and 90 were classified as normal vascular aging (NVA) and those with a percentile below 10 were classified as healthy vascular aging (HVA). Physical activity was analyzed through the short version of the Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ).

RESULTS

The mean age of the participants was 61.34 ± 7.70 years, with 61.60% men. Of the total sample, 86% were sedentary (83% men vs 90% women). The total physical activity showed a negative association with baPWV (β = - 0.045; 95% CI - 0.080 to - 0.009). Intense physical activity showed a negative relationship with baPWV (β = - 0.084; 95% CI - 0.136 to - 0.032). The OR of the total physical activity and the intense physical activity carried out by the subjects classified as NVA with respect to those classified as HVA was OR = 0.946; (95% CI 0.898 to 0.997) and OR = 0.903; (95% CI 0.840 to 0.971), and of those classified as EVA it was OR = 0.916; (95% CI 0.852 to 0.986) and OR = 0.905; (95% CI 0.818 to 1.000). No association was found with moderate- or low-intensity physical activity.

CONCLUSIONS

The results of this study suggest that, when intense physical activity is performed, the probability of presenting vascular aging is lower. In the analysis by sex, this association is only observed in men.

摘要

背景

本研究旨在分析西班牙具有中等心血管风险的人群中，体力活动及其强度与动脉僵硬和血管老化的相关性，并分析其性别差异。

方法

这是一项横断面研究。共有 2475 名 35-75 岁的个体参与了这项研究。使用 VaSera VS-1500 设备测量肱踝脉搏波速度（baPWV）。根据参与者的年龄和性别百分位数，将参与者分为以下几类：百分位数高于 90 并伴有已确诊心血管疾病的患者被归类为早期血管老化（EVA）；百分位数在 10-90 之间的被归类为正常血管老化（NVA），百分位数低于 10 的被归类为健康血管老化（HVA）。通过明尼苏达州休闲时间体力活动问卷（MLTPAQ）的短版分析体力活动。

结果

参与者的平均年龄为 61.34±7.70 岁，其中 61.60%为男性。在总样本中，86%的人是久坐不动的（83%为男性，90%为女性）。总体力活动与 baPWV 呈负相关（β=-0.045；95%CI -0.080 至-0.009）。高强度体力活动与 baPWV 呈负相关（β=-0.084；95%CI -0.136 至-0.032）。与被归类为 HVA 的受试者相比，被归类为 NVA 的受试者进行的总体力活动和高强度体力活动的 OR 分别为 0.946（95%CI 0.898 至 0.997）和 0.903（95%CI 0.840 至 0.971），而被归类为 EVA 的 OR 分别为 0.916（95%CI 0.852 至 0.986）和 0.905（95%CI 0.818 至 1.000）。与中强度或低强度体力活动无相关性。