Department of Biology, University of Pennsylvania, School of Arts and Sciences, Philadelphia, PA 19104, USA.
Department of Biology, University of Pennsylvania, School of Arts and Sciences, Philadelphia, PA 19104, USA.
Curr Opin Plant Biol. 2022 Oct;69:102287. doi: 10.1016/j.pbi.2022.102287. Epub 2022 Aug 18.
Our recent cognizance of diverse RNA classes undergoing dynamic covalent chemical modifications (or epitranscriptomic marks) in plants has provided fresh insight into the underlying molecular mechanisms of gene expression regulation. Comparatively, epigenetic marks comprising heritable modifications of DNA and histones have been extensively studied in plants and their impact on plant gene expression is quite established. Based on our growing knowledge of the plant epitranscriptome and epigenome, it is logical to explore how the two regulatory layers intermingle to intricately determine gene expression levels underlying key biological processes such as development and response to stress. Herein, we focus on the emerging evidence of crosstalk between the plant epitranscriptome with epigenetic regulation involving DNA modification, histone modification, and non-coding RNAs.
我们最近认识到，植物中多种 RNA 类别经历动态共价化学修饰（或转录后修饰标记），这为基因表达调控的潜在分子机制提供了新的见解。相比之下，包含 DNA 和组蛋白遗传修饰的表观遗传标记在植物中已得到广泛研究，并且其对植物基因表达的影响已得到充分证实。基于我们对植物转录后组和表观基因组日益增长的认识，探讨这两个调控层如何相互交织，从而精细地决定关键生物学过程（如发育和应激反应）的基因表达水平是合乎逻辑的。在此，我们重点介绍植物转录后组与涉及 DNA 修饰、组蛋白修饰和非编码 RNA 的表观遗传调控之间相互作用的新证据。
