Department of Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China.
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China.
Theranostics. 2021 Mar 4;11(9):4549-4566. doi: 10.7150/thno.54967. eCollection 2021.
Epigenetic regulation involves a range of sophisticated processes which contribute to heritable alterations in gene expression without altering DNA sequence. Regulatory events predominantly include DNA methylation, chromatin remodeling, histone modifications, non-coding RNAs (ncRNAs), and RNA modification. As the most prevalent RNA modification in eukaryotic cells, N-methyladenosine (mA) RNA methylation actively participates in the modulation of RNA metabolism. Notably, accumulating evidence has revealed complicated interrelations occurring between mA and other well-known epigenetic modifications. Their crosstalk conspicuously triggers epigenetic remodeling, further yielding profound impacts on a variety of physiological and pathological processes, especially tumorigenesis. Herein, we provide an up-to-date review of this emerging hot area of biological research, summarizing the interplay between mA RNA methylation and other epigenetic regulators, and highlighting their underlying functions in epigenetic reprogramming.
表观遗传调控涉及一系列复杂的过程，这些过程有助于基因表达的可遗传改变，而不会改变 DNA 序列。调节事件主要包括 DNA 甲基化、染色质重塑、组蛋白修饰、非编码 RNA(ncRNA)和 RNA 修饰。作为真核细胞中最普遍的 RNA 修饰，N6-甲基腺苷(m6A)RNA 甲基化积极参与 RNA 代谢的调节。值得注意的是，越来越多的证据表明 m6A 与其他著名的表观遗传修饰之间存在复杂的相互关系。它们的串扰显著引发表观遗传重塑，进一步对多种生理和病理过程产生深远影响，特别是肿瘤发生。本文就这一新兴的生物学研究热点领域进行了综述，总结了 m6A RNA 甲基化与其他表观遗传调控因子之间的相互作用，并强调了它们在表观遗传重编程中的潜在功能。
