Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands; Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, United States.
Department of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, United States; Division of Gastroenterology and Hepatology, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates.
Best Pract Res Clin Gastroenterol. 2022 Jun-Aug;58-59:101783. doi: 10.1016/j.bpg.2021.101783. Epub 2022 Jan 3.
Pancreatic cancer is one of the deadliest malignancies. Therefore, there is an urgent need to detect pancreatic cancer in an earlier stage to improve outcomes. A variety of hereditary cancer syndromes have been associated with an increased risk of developing pancreatic cancer, and these individuals may benefit from surveillance programs. Surveillance programs have shown potential to improve outcomes, but have important risks such as overtreatment. In this review we will discuss the definitions and epidemiology of hereditary pancreatic cancer, recommendations for genetic testing and participation in surveillance. Important aspects are differences in surveillance strategies, target lesions, and potential benefits and harms of surveillance. Lastly we will highlight future directions for research and improvement of care for individuals at high-risk of pancreatic cancer.
胰腺癌是最致命的恶性肿瘤之一。因此，迫切需要更早地发现胰腺癌，以改善预后。多种遗传性癌症综合征与胰腺癌发病风险增加相关，这些个体可能受益于监测计划。监测计划显示出改善预后的潜力，但存在过度治疗等重要风险。在这篇综述中，我们将讨论遗传性胰腺癌的定义和流行病学，以及基因检测和参与监测的建议。重要的方面是监测策略、靶病变以及监测的潜在益处和危害的差异。最后，我们将强调未来研究和改善高危胰腺癌个体护理的方向。
