载 TiC/AuNRs 的近红外/ pH 响应壳聚糖水凝胶，具有近红外触发的光热效应。
NIR/pH-responsive chitosan hydrogels containing TiC/AuNRs with NIR-triggered photothermal effect.
机构信息
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China.
People's Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450003, China.
出版信息
Carbohydr Polym. 2022 Nov 1;295:119853. doi: 10.1016/j.carbpol.2022.119853. Epub 2022 Jul 12.
Remotely multi-responsive chitosan (CS) hydrogels holds great promise in the design of anticancer drug carriers. In this paper, near-infrared (NIR)-/pH-dual responsive CS/β-GP/TiC@AuNRs hybrid hydrogel was prepared based on CS/β-glycerol phosphate disodium salt (β-GP) crosslinking system embedded with NIR-responsive TiC@gold nanorods (AuNRs) nanosheets. Excess β-GP promoted the formation of massive electronegative cavities, which endowed hybrid hydrogels with high drug loading efficiency for electropositive DOX (around 88.5 %). The collapse of chitosan network in acidic medium gave the hybrid hydrogel with distinct pH response. In addition, the distinct temperature increase owing to the strong NIR responsiveness of TiC@AuNRs nanosheets would accelerate the DOX release dramatically. Therefore, NIR-, pH- and thermal-multi-responsiveness would synergistically endow CS/β-GP/TiC@AuNRs hybrid hydrogel with notable NIR-triggered photothermal effect and remotely controllable drug delivery properties.
远程多重响应壳聚糖（CS）水凝胶在设计抗癌药物载体方面具有广阔的前景。本文基于 CS/β-甘油磷酸二钠盐（β-GP）交联体系，制备了近红外（NIR）/pH 双重响应 CS/β-GP/TiC@AuNRs 杂化水凝胶，其中嵌入了 NIR 响应性 TiC@金纳米棒（AuNRs）纳米片。过量的 β-GP 促进了大量带负电空腔的形成，使杂化水凝胶对正电性 DOX（约 88.5%）具有高载药效率。在酸性介质中，壳聚糖网络的塌陷使杂化水凝胶具有明显的 pH 响应性。此外，由于 TiC@AuNRs 纳米片具有很强的 NIR 响应性，会产生明显的温度升高，从而显著加速 DOX 的释放。因此，NIR、pH 和热多重响应性将协同赋予 CS/β-GP/TiC@AuNRs 杂化水凝胶显著的 NIR 触发光热效应和远程可控药物输送性能。
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