Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
Longevity Institute and Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; IFOM, FIRC Institute of Molecular Oncology, Via Adamello, 16, Milano 20139, Italy.
Phys Med Rehabil Clin N Am. 2022 Aug;33(3):699-717. doi: 10.1016/j.pmr.2022.04.009. Epub 2022 Jun 23.
Worldwide obesity has risen to record levels generating a major risk factor for metabolic syndrome, diabetes, hypertension, and cardiovascular disease as well as cancer and neurodegenerative diseases. Here we discuss the impact of obesity on lifespan and cardiometabolic disease in mice and humans and how different types of fasting can help prevent and treat them. We argue that specific types of fasting regimens which are associated with low burden, high long-term compliance and safety, can reduce obesity and other disease risk factors, lower morbidity and extend healthspan.
全球肥胖率已上升至创纪录水平，成为代谢综合征、糖尿病、高血压和心血管疾病以及癌症和神经退行性疾病的主要危险因素。在这里，我们讨论肥胖对小鼠和人类寿命和心脏代谢疾病的影响，以及不同类型的禁食如何帮助预防和治疗这些疾病。我们认为，与低负担、高长期依从性和安全性相关的特定类型的禁食方案可以减少肥胖和其他疾病风险因素，降低发病率并延长健康寿命。
