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肥胖与寿命,一场复杂的探戈。

Obesity and lifespan, a complex tango.

机构信息

Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Laboratory of Cellular and Molecular Gerontology, Precision Nutrition and Aging, IMDEA Food, CEI UAM + CSIC, 028049 Madrid, Spain.

出版信息

Sci Transl Med. 2023 Nov 22;15(723):eadh1175. doi: 10.1126/scitranslmed.adh1175.

DOI:10.1126/scitranslmed.adh1175
PMID:37992154
Abstract

Obesity and aging share comorbidities, phenotypes, and deleterious effects on health that are associated with chronic diseases. However, distinct features set them apart, with underlying biology that should be explored and exploited, especially given the demographic shifts and the obesity epidemic that the world is facing.

摘要

肥胖症和衰老存在共病、表型和对健康的有害影响,这些与慢性疾病有关。然而,它们也有明显的区别,其潜在的生物学特性值得我们去探索和利用,尤其是考虑到世界正面临的人口结构变化和肥胖症流行这两大问题。

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Nutrition and Exercise Interventions to Improve Body Composition for Persons with Overweight or Obesity Near Retirement Age: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.营养与运动干预对改善临近退休超重或肥胖人群身体成分的效果:一项随机对照试验的系统评价和网络荟萃分析。
Adv Nutr. 2023 May;14(3):516-538. doi: 10.1016/j.advnut.2023.04.001. Epub 2023 Apr 6.
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Hallmarks of aging: An expanding universe.衰老的特征:一个不断扩大的领域。
Cell. 2023 Jan 19;186(2):243-278. doi: 10.1016/j.cell.2022.11.001. Epub 2023 Jan 3.
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Myokine, a key cytokine for physical exercise to alleviate sarcopenic obesity.
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J Cachexia Sarcopenia Muscle. 2025 Jun;16(3):e13824. doi: 10.1002/jcsm.13824.
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The impact of internet medical service on rural gender inequality in health opportunity: a cross-sectional study.互联网医疗服务对农村健康机会性别不平等的影响:一项横断面研究。
BMC Public Health. 2024 Nov 8;24(1):3093. doi: 10.1186/s12889-024-20575-w.
5
ER-phagy drives age-onset remodeling of endoplasmic reticulum structure-function and lifespan.内质网自噬驱动内质网结构功能和寿命的衰老相关重塑。
bioRxiv. 2024 Aug 8:2024.08.07.607085. doi: 10.1101/2024.08.07.607085.
肌动蛋白,一种运动缓解肌肉减少性肥胖的关键细胞因子。
Mol Biol Rep. 2023 Mar;50(3):2723-2734. doi: 10.1007/s11033-022-07821-3. Epub 2022 Dec 26.
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Nat Med. 2022 Dec;28(12):2521-2529. doi: 10.1038/s41591-022-02100-x. Epub 2022 Dec 8.
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Depot-specific adipose tissue modulation by SGLT2 inhibitors and GLP1 agonists mediates their cardioprotective effects in metabolic disease.
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