Yan Yujia, Zhang Xiqiang, An Xingwei, Fan Wanpeng, Liang Jingbo, Luo Bin, Ren Hecheng, Huang Ying
Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China.
Front Neurol. 2022 Aug 5;13:928802. doi: 10.3389/fneur.2022.928802. eCollection 2022.
Stroke has become a significant cause of death and disability globally. Along with the transition of the world's aging population, the incidence of acute ischemic stroke is increasing year by year. Even with effective treatment modalities, patients are not guaranteed to have a good prognosis. The treatment model combining intravenous thrombolysis/endovascular therapy and neuroprotection is gradually being recognized. After the clinical translation of pharmacological neuroprotective agents failed, non-pharmacological physical neuroprotective agents have rekindled hope. We performed a literature review using the National Center for Biotechnology Information (NCBI) PubMed database for studies that focused on the application of hyperbaric oxygen therapy in acute ischemic stroke. In this review, we present the history and mechanisms of hyperbaric oxygen therapy, focusing on the current status, outcomes, current challenges, perspective, safety, and complications of the application of hyperbaric oxygen in animal experiments and human clinical trials. Hyperbaric oxygen therapy, a non-pharmacological treatment, can improve the oxygenation level at the ischemic lesions in increased dissolved oxygen and oxygen diffusion radius to achieve salvage of neurological function, giving a new meaning to acute ischemic stroke.
中风已成为全球范围内死亡和残疾的重要原因。随着全球人口老龄化的加剧，急性缺血性中风的发病率逐年上升。即使采用有效的治疗方式，也不能保证患者有良好的预后。静脉溶栓/血管内治疗与神经保护相结合的治疗模式正逐渐得到认可。在药理学神经保护剂的临床转化失败后，非药理学物理神经保护剂重新燃起了希望。我们使用美国国立生物技术信息中心（NCBI）的PubMed数据库进行了文献综述，以查找专注于高压氧疗法在急性缺血性中风中应用的研究。在本综述中，我们介绍了高压氧疗法的历史和机制，重点关注其在动物实验和人体临床试验中的应用现状、结果、当前挑战、前景、安全性和并发症。高压氧疗法作为一种非药物治疗方法，可通过增加溶解氧和氧扩散半径来提高缺血病灶处的氧合水平，从而实现神经功能的挽救，为急性缺血性中风赋予了新的意义。
