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慢性创伤性脊髓损伤合并神经源性下尿路功能障碍患者的泌尿系统并发症及长期治疗依从性

Urinary system complications and long-term treatment compliance in chronic traumatic spinal cord injury patients with neurogenic lower urinary tract dysfunction.

作者信息

Dere Çağlayan, Dere Didem, Paker Nurdan, Buğdaycı Soy Derya, Ersoy Sedef

机构信息

Department of Physical Medicine and Rehabilitation, Kocaeli Darıca Farabi Traning Hospital, Kocaeli, Türkiye.

Department of Physical Medicine and Rehabilitation, Istanbul Physical Medicine and Rehabilitation Training and Research Hospital, Istanbul, Türkiye.

出版信息

Turk J Phys Med Rehabil. 2022 Jun 1;68(2):278-285. doi: 10.5606/tftrd.2022.7719. eCollection 2022 Jun.

Abstract

OBJECTIVES

The aim of this study was to evaluate upper and lower urinary tract complications and the compliance of long-term treatment in patients with spinal cord injury (SCI) by urodynamic examination.

PATIENTS AND METHODS

Between January 1997 and May 2007, a total of 89 patients with SCI (79 males, 19 females; mean age: 39.8±12.2 years; range, 19 to 72 years) who were admitted to physical medicine and rehabilitation clinic were retrospectively analyzed. Demographic, neurological, and urodynamic data of the patients with the diagnosis of neurogenic lower urinary tract dysfunction (NLUTD) in their initial urodynamic examination and without regular follow-up were recorded.

RESULTS

The mean time to the first urodynamic examination was 8.6±5.4 months. Sixty-seven patients who had neurogenic detrusor overactivity (NDO) in their first urodynamic tests were recommended anticholinergics. Clean intermittent catheterization (CIC) was recommended after initial urodynamic examination in all patients. Thirty-nine patients of 67 who had NDO were taking medications, while 28 were not. In the patients who continued anticholinergic treatment, bladder capacity was found to statistically significantly increase, compared to the initial measurement values and detrusor pressures significantly decreased (p<0.001). The compliance rate with CIC and anticholinergic treatment was 79.8% and 58.2%, respectively. Sixteen of the patients had calculus in the urinary system. Forty-two patients had infections more than once a year and used antibiotics.

CONCLUSION

Neurogenic bladder should be evaluated at the beginning of SCI and, then, followed on a regular basis. Urodynamic tests should be performed immediately after spinal shock and can be repeated, as indicated.

摘要

目的

本研究旨在通过尿动力学检查评估脊髓损伤(SCI)患者的上、下尿路并发症及长期治疗的依从性。

患者与方法

回顾性分析1997年1月至2007年5月期间收治于物理医学与康复门诊的89例SCI患者(男79例,女19例;平均年龄:39.8±12.2岁;范围19至72岁)。记录患者初次尿动力学检查诊断为神经源性下尿路功能障碍(NLUTD)且未进行定期随访时的人口统计学、神经学和尿动力学数据。

结果

初次尿动力学检查的平均时间为8.6±5.4个月。67例初次尿动力学检查显示有神经源性逼尿肌过度活动(NDO)的患者被建议使用抗胆碱能药物。所有患者在初次尿动力学检查后均被建议进行清洁间歇性导尿(CIC)。67例有NDO的患者中,39例正在服药,28例未服药。在继续抗胆碱能治疗的患者中,与初始测量值相比,膀胱容量在统计学上显著增加,逼尿肌压力显著降低(p<0.001)。CIC和抗胆碱能治疗的依从率分别为79.8%和58.2%。16例患者泌尿系统有结石。42例患者每年感染超过一次并使用抗生素。

结论

应在SCI发病初期对神经源性膀胱进行评估,然后定期随访。脊髓休克后应立即进行尿动力学检查,并可根据需要重复检查。

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