Huang Yingjie, Yin Zhijie, Han Wei
Department of Pancreatic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Front Oncol. 2025 Jul 15;15:1546400. doi: 10.3389/fonc.2025.1546400. eCollection 2025.
BACKGROUND: Pancreatic cancer liver metastasis (PCLM) is a critical condition characterized by the spread of pancreatic cancer to the liver, significantly contributing to cancer-related mortality. The importance of understanding the epidemiology and research trends in PCLM cannot be overstated, as it impacts the development of effective treatment strategies and patient care in oncology. METHOD: This study provides a comprehensive epidemiological and bibliometric analysis of PCLM research. Advanced visualization tools such as VOSviewer, CiteSpace, and the R package "bibliometrix" were utilized to analyze the literature. A total of 3,941 publications were identified, covering a 15-year period from 2010 to 2024. The methodology included the identification of publication trends, country and institutional contributions, leading journals, and keyword co-occurrence analysis to uncover research hotspots. RESULTS: The annual publication counts exhibited an upward trend, peaking at 384 in 2024, indicating a growing interest in PCLM research. The research included contributions from 90 countries and 4386 institutions, with China and the United States being the most prolific. The journal was identified as the most frequent publisher in this field. Keyword co-occurrence analysis revealed "cancer" and "pancreatic cancer" as key research hotspots, with a focus on prognostic factors and therapeutic strategies. The study also highlighted the importance of international collaboration and identified key contributors in the field. CONCLUSION: The findings of this study reveal the significant increase in PCLM research output, emphasizing the need for continued investigation and collaboration to improve treatment outcomes and patient care. While the study is limited by its reliance on bibliometric data without experimental validation, it nonetheless provides valuable insights into publication trends and emerging research themes in PCLM. The results underscore the importance of further research to enhance our understanding of this challenging area of oncology and to guide future research directions.
背景：胰腺癌肝转移（PCLM）是一种危急病症，其特征是胰腺癌扩散至肝脏，这在很大程度上导致了癌症相关的死亡率。了解PCLM的流行病学和研究趋势的重要性再怎么强调都不为过，因为它影响着肿瘤学中有效治疗策略的制定和患者护理。 方法：本研究对PCLM研究进行了全面的流行病学和文献计量分析。利用VOSviewer、CiteSpace和R包“bibliometrix”等先进的可视化工具对文献进行分析。共识别出3941篇出版物，涵盖2010年至2024年的15年期间。该方法包括确定出版趋势、国家和机构的贡献、主要期刊以及关键词共现分析以揭示研究热点。 结果：年度出版物数量呈上升趋势，在2024年达到峰值384篇，表明对PCLM研究的兴趣日益浓厚。该研究涵盖了90个国家和4386个机构的贡献，中国和美国的贡献最为突出。该期刊被确定为该领域最频繁的出版商。关键词共现分析显示“癌症”和“胰腺癌”是关键研究热点，重点关注预后因素和治疗策略。该研究还强调了国际合作的重要性，并确定了该领域的关键贡献者。 结论：本研究结果揭示了PCLM研究产出的显著增加，强调需要持续进行调查和合作以改善治疗效果和患者护理。虽然该研究受到依赖文献计量数据而未进行实验验证的限制，但它仍然为PCLM的出版趋势和新兴研究主题提供了有价值的见解。结果强调了进一步研究的重要性，以加深我们对肿瘤学这一具有挑战性领域的理解，并指导未来的研究方向。
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