Butchart Sara, Candow Darren G, Forbes Scott C, Mang Cameron S, Gordon Julianne J, Ko Jongbum, Deprez Dalton, Chilibeck Philip D, Ditor David S
Faculty of Kinesiology and Health Studies, University of Regina, Regina, SK, CANADA.
Department of Physical Education Studies, Brandon University, Brandon, MB, CANADA.
Int J Exerc Sci. 2022 Aug 1;15(2):1117-1132. doi: 10.70252/EKHJ1489. eCollection 2022.
The purpose was to investigate the effects of progressive resistance training (PRT) and creatine supplementation in stroke survivors. Participants were randomized to one of two groups: creatine ( = 5; 51 ± 16y) or placebo ( = 3; 73 ± 8y) during 10 weeks of supervised PRT. Prior to and following PRT and supplementation, assessments were made for body composition (lean tissue and fat mass), muscle thickness, muscle strength (1-repetition maximum), functional exercise capacity (6-minute walk test, Berg Balance Scale; BBS), cognition (Montreal Cognitive Assessment; MoCA), and symptoms of anxiety (Generalized Anxiety Disorder Assessment-7; GAD-7) and depression (Center for Epidemiological Studies Depression Scale; CES-D). There were time main effects for leg press strength (increased; = 0.001), chest press strength (increased; = 0.003), elbow flexor muscle thickness (increased; = 0.007), BBS (increased; = 0.002), MoCA (increased; = 0.031) and CES-D (decreased; = 0.045). There was a group x time interaction for the 6 minute walk test ( = 0.039). The creatine group significantly increased walking distance over time ( = 0.002) with no change in the placebo group ( = 0.120). Ten weeks of PRT had some positive effects on measures of muscle strength and size, balance, cognition and depression. The addition of creatine to PRT significantly improved walking performance in stroke survivors.
目的是研究渐进性抗阻训练（PRT）和补充肌酸对中风幸存者的影响。参与者被随机分为两组之一：在为期10周的有监督的PRT期间，肌酸组（n = 5；51±16岁）或安慰剂组（n = 3；73±8岁）。在PRT和补充剂之前及之后，对身体成分（瘦组织和脂肪量）、肌肉厚度、肌肉力量（1次重复最大值）、功能运动能力（6分钟步行试验、伯格平衡量表；BBS）、认知（蒙特利尔认知评估；MoCA）以及焦虑症状（广泛性焦虑障碍评估量表-7；GAD-7）和抑郁症状（流行病学研究中心抑郁量表；CES-D）进行评估。在腿举力量（增加；P = 0.001）、卧推力量（增加；P = 0.003）、肘屈肌肌肉厚度（增加；P = 0.007）、BBS（增加；P = 0.002）、MoCA（增加；P = 0.031）和CES-D（降低；P = 0.045）方面存在时间主效应。在6分钟步行试验方面存在组×时间交互作用（P = 0.039）。随着时间推移，肌酸组的步行距离显著增加（P = 0.002），而安慰剂组无变化（P = 0.120）。10周的PRT对肌肉力量和大小、平衡、认知和抑郁指标有一些积极影响。在PRT中添加肌酸可显著改善中风幸存者的步行表现。
