破坏miR-132与3'非翻译区之间的相互作用可改善小鼠的突触可塑性和记忆力。
Disrupting interaction between miR-132 and 3'UTR improves synaptic plasticity and memory in mice.
作者信息
Kuzniewska Bozena, Rejmak Karolina, Nowacka Agata, Ziółkowska Magdalena, Milek Jacek, Magnowska Marta, Gruchota Jakub, Gewartowska Olga, Borsuk Ewa, Salamian Ahmad, Dziembowski Andrzej, Radwanska Kasia, Dziembowska Magdalena
机构信息
Laboratory of Molecular Basis of Synaptic Plasticity, Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Laboratory of Molecular Basis of Behavior, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, Poland.
出版信息
Front Mol Neurosci. 2022 Aug 5;15:924534. doi: 10.3389/fnmol.2022.924534. eCollection 2022.
As microRNAs have emerged to be important regulators of molecular events occurring at the synapses, the new questions about their regulatory effect on the behavior have araised. In the present study, we show for the first time that the dysregulated specific targeting of miR132 to mRNA in the mouse brain results in the increased level of Mmp9 protein, which affects synaptic plasticity and has an effect on memory formation. Our data points at the importance of complex and precise regulation of the Mmp9 level by miR132 in the brain.
由于微小RNA已成为突触处发生的分子事件的重要调节因子，关于它们对行为的调节作用产生了新的问题。在本研究中，我们首次表明，小鼠大脑中miR132对mRNA的特异性靶向失调会导致Mmp9蛋白水平升高，这会影响突触可塑性并对记忆形成产生影响。我们的数据表明，大脑中miR132对Mmp9水平进行复杂而精确的调节具有重要意义。
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