Bioprocess Intensification Group, Federal University of Santa Maria, 97105-900, Santa Maria, RS, Brazil.
Recent Pat Biotechnol. 2023;17(4):296-311. doi: 10.2174/1872208316666220820092643.
There is a current tendency towards bioactive natural products that can be used in different areas such as food, pharmaceutical, and biomedical. In the last decades, polysaccharides have attracted increasing interest because of their potent nontoxic effects, therapeutic properties, and diversified range of applications. Polysaccharides are complex and heterogeneous macromolecules constituted of different monosaccharides and, in some cases, of glucuronic acid and sulphate groups. Polysaccharides with biological activity can be derived from plants, animals and microorganisms, especially microalgae. Microalgae are considered one of the most promising sources of these compounds that have already proved to have several important biological properties. In this sense, our objective is to elucidate the use of bioactive polysaccharides from microalgae in biomedical applications, emphasizing the biological activity of these compounds. Furthermore, the microalgal biomass production systems and polysaccharides extraction methods were presented and discussed.
目前有一个趋势是利用具有生物活性的天然产物,这些产物可以应用于食品、制药和生物医学等不同领域。在过去几十年中,由于多糖具有无毒、治疗效果好且应用范围广等特点,因此越来越受到人们的关注。多糖是由不同的单糖组成的复杂异质大分子,在某些情况下还含有葡萄糖醛酸和硫酸基团。具有生物活性的多糖可以从植物、动物和微生物中提取,特别是微藻。微藻被认为是这些化合物最有前途的来源之一,因为它们已经被证明具有多种重要的生物学特性。因此,我们的目标是阐明生物活性多糖在生物医学中的应用,强调这些化合物的生物活性。此外,还介绍和讨论了微藻生物质生产系统和多糖提取方法。