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海洋微藻塔玛斯鱼腥藻中分离得到的多糖具有很强的生物医学应用潜力。

Potent biomedical applications of isolated polysaccharides from marine microalgae Tetraselmis species.

机构信息

Department of Life Sciences, College of Bionano, Gachon University, Seongnamdaero 1342, Seongnam-si, Gyeonggi-do, 461-701, Republic of Korea.

Department of Biomedical Engineering, College of Health Science, Gachon University, Incheon, 21936, Republic of Korea.

出版信息

Bioprocess Biosyst Eng. 2018 Nov;41(11):1611-1620. doi: 10.1007/s00449-018-1987-z. Epub 2018 Aug 22.

Abstract

Microalgae Tetraselmis species were used to evaluate the biological characteristics of water-soluble polysaccharides (WSPs) as one of the significant bioactive substances (BAS) from these photosynthetic microalgae species. Compositional analysis of these BAS shows that they are mainly composed of WSPs along with negligible amount of proteins and lipids. WSPs were partially purified and characterized for their compositional, structural and biological properties such as antioxidant, tyrosinase inhibitory activity and antifungal activies. These WSPs showed the significant antioxidant, antifungal and tyrosinase inhibitory activities, respectively. The outcomes of this study demonstrated that WSPs can be the potent source of biological moieties for further investigations along with specific potent biological activities.

摘要

微藻塔斯马尼亚菱形藻被用来评估水溶性多糖(WSPs)的生物学特性,WSPs 是这些光合微藻物种的重要生物活性物质(BAS)之一。这些 BAS 的成分分析表明,它们主要由 WSPs 组成,同时含有极少量的蛋白质和脂质。WSPs 被部分纯化并对其组成、结构和生物学特性进行了表征,如抗氧化、酪氨酸酶抑制活性和抗真菌活性。这些 WSPs 分别表现出显著的抗氧化、抗真菌和酪氨酸酶抑制活性。本研究的结果表明,WSPs 可以作为潜在的生物活性物质来源,进一步研究其具有特定生物活性的化合物。

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