Department of Bioengineering, Integral University, Lucknow, Uttar Pradesh, 226026, India.
School of Biochemical Engineering, IIT(BHU), Varanasi 221005, India.
Recent Pat Biotechnol. 2024;18(3):190-209. doi: 10.2174/1872208317666230623141740.
Algae is emerging as a bioresource with high biological potential. Various algal strains have been used in traditional medicines and human diets worldwide. They are a rich source of bioactive compounds like ascorbic acid, riboflavin, pantothenate, biotin, folic acid, nicotinic acid, phycocyanins, gamma-linolenic acid (GLA), adrenic acid (ARA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), etc. Beta-carotene, astaxanthin, and phycobiliproteins are different classes of pigments that are found in algae. They possess antioxidant, anti-inflammatory and anticancer properties. The sulfur-coated polysaccharides in algae have been used as an anticancer, antibacterial, and antiviral agent. Scientists have exploited algal-derived bioactive compounds for developing lead molecules against several diseases. Due to the surge in research on bioactive molecules from algae, industries have started showing interest in patenting for the large-scale production of bioactive compounds having applications in sectors like pharmaceuticals, food, and beverage. In the food industry, algae are used as a thickening, gelling, and stabilizing agent. Due to their gelling and thickening characteristics, the most valuable algae products are macroalgal polysaccharides such as agar, alginates, and carrageenan. The high protein, lipid, and nutrient content in microalgae makes it a superfood for aquaculture. The present review aims at describing various non-energy-based applications of algae in pharmaceuticals, food and beverage, cosmetics, and nutraceuticals. This review attempts to analyze information on algal-derived drugs that have shown better potential and reached clinical trials.
藻类作为一种具有高生物潜力的生物资源正在兴起。世界各地的传统医学和人类饮食中都使用了各种藻类菌株。它们是生物活性化合物的丰富来源,如抗坏血酸、核黄素、泛酸、生物素、叶酸、烟酸、藻蓝蛋白、γ-亚麻酸(GLA)、花生四烯酸(ARA)、二十二碳六烯酸(DHA)、二十碳五烯酸(EPA)等。β-胡萝卜素、虾青素和藻胆蛋白是藻类中不同类别的色素。它们具有抗氧化、抗炎和抗癌特性。藻类中的含硫多糖已被用作抗癌、抗菌和抗病毒药物。科学家们已经利用藻类衍生的生物活性化合物来开发针对多种疾病的先导分子。由于对藻类生物活性分子的研究激增,各行业开始对藻类生物活性化合物的专利产生兴趣,这些化合物在制药、食品和饮料等领域具有应用价值。在食品工业中,藻类被用作增稠剂、胶凝剂和稳定剂。由于其胶凝和增稠特性,最有价值的藻类产品是大型藻类多糖,如琼脂、藻酸盐和卡拉胶。微藻中的高蛋白、脂质和营养含量使其成为水产养殖的超级食品。本综述旨在描述藻类在制药、食品和饮料、化妆品和营养保健品中的各种非能源应用。本综述试图分析具有更好潜力并已进入临床试验的藻类衍生药物的信息。