Department of Neurology, Mayo Clinic Scottsdale, Scottsdale, AZ, USA.
Curr Neurol Neurosci Rep. 2022 Oct;22(10):625-634. doi: 10.1007/s11910-022-01225-3. Epub 2022 Aug 22.
We explore the anatomy of the central and peripheral autonomic pathways involved in primary headache as well as the mechanisms for secondary headache associated with disorders of the autonomic nervous system. The prevalence and clinical presentation of cranial and systemic autonomic symptoms in these conditions will be discussed, with a focus on recent studies.
Several small studies have utilized the relationship between headache and the autonomic nervous system to identify potential biomarkers to aid in diagnosis of migraine and cluster headache. Headache in postural orthostatic tachycardia syndrome (POTS) has also been further characterized, particularly in its association with orthostatic headache and spontaneous intracranial hypotension (SIH). This review examines the pathophysiology of primary and secondary headache disorders in the context of the autonomic nervous system. Mechanisms of headache associated with systemic autonomic disorders are also reviewed.
我们探讨了原发性头痛中涉及中枢和外周自主神经通路的解剖结构，以及与自主神经系统障碍相关的继发性头痛的机制。将讨论这些情况下颅神经和全身自主症状的患病率和临床表现，并重点介绍最近的研究。
几项小型研究利用头痛与自主神经系统之间的关系来确定潜在的生物标志物，以辅助偏头痛和丛集性头痛的诊断。体位性心动过速综合征 (POTS) 中的头痛也得到了进一步描述，特别是其与直立性头痛和自发性颅内低血压 (SIH) 的关系。这篇综述检查了自主神经系统背景下原发性和继发性头痛障碍的病理生理学。还回顾了与全身自主神经障碍相关的头痛机制。
