Department of Global Public Health, Karolinska Institutet, Solna, Sweden.
Department of Global Public Health, Karolinska Institutet, Solna, Sweden; Centre for Psychiatry Research, Sweden, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Services, 114 35 Stockholm, Sweden.
Drug Alcohol Depend. 2022 Oct 1;239:109601. doi: 10.1016/j.drugalcdep.2022.109601. Epub 2022 Aug 10.
To compare the effects of yoga, aerobic exercise, and usual care on anxiety and depressive symptoms in non-treatment seeking adults with AUD.
Parallel, three-group, open-label randomised (1:1:1) controlled trial with blinded follow-up assessment. Non-treatment seeking adults (aged 18-75 years) were recruited via advertisements in a free newspaper in Stockholm, Sweden. All participants had clinician-diagnosed AUD prior to randomisation. This trial excluded those who were physically active, or for whom supervised physical activity was contraindicated. Participants were randomly assigned to 12-weeks of aerobic exercise, yoga, or usual care (telephone counselling). The secondary outcome of interest was the Hospital Anxiety and Depression Scale (HADS), assessed at baseline and 12-week follow-up. Primary analyses consisted of linear regression models and followed intention-to-treat (ITT) principals.
In total, 140 participants (mean age 53.7 years, SD=11.8) were recruited. Follow-up was completed for 42/45 participants randomised to TAU, 42/49 to aerobic exercise and 43/46 to yoga. ITT analyses included 126 trial participants. There were statistically significant within-group improvements in total HADS in all three intervention groups. Effect sizes for usual care and aerobic exercise were small (Hedges' g=0.48, 95% CI=0.16, 0.80 and g=0.41, 95% CI=0.09, 0.72, respectively), while yoga was associated with a large treatment effect (g=1.06, 95% CI=0.69, 1.43). There were significant between-group differences in these improvements favouring yoga (B=-2.15, 95% CI=-4.16, -0.15, p = .035) relative to usual care, but no significant differences between yoga and aerobic exercise. No injuries were reported.
Findings support the recommendation of yoga for non-treatment seeking adults with AUD.
比较瑜伽、有氧运动和常规护理对未经治疗的 AUD 成人焦虑和抑郁症状的影响。
平行、三组、开放标签随机（1:1:1）对照试验，盲法随访评估。未经治疗的成年人（年龄 18-75 岁）通过在瑞典斯德哥尔摩的免费报纸上刊登广告招募。所有参与者在随机分组前均被临床诊断为 AUD。该试验排除了那些身体活跃或不适合监督体育活动的人。参与者被随机分配到 12 周的有氧运动、瑜伽或常规护理（电话咨询）。主要观察指标为医院焦虑和抑郁量表（HADS），在基线和 12 周随访时进行评估。主要分析包括线性回归模型，并遵循意向治疗（ITT）原则。
共有 140 名参与者（平均年龄 53.7 岁，标准差=11.8）被招募。45 名参与者随机分配至 TAU 组、49 名参与者随机分配至有氧运动组和 46 名参与者随机分配至瑜伽组的参与者完成了随访。ITT 分析包括 126 名试验参与者。所有三组干预组的 HADS 总分均有显著的组内改善。常规护理和有氧运动的效应量较小（Hedges'g=0.48，95%CI=0.16，0.80 和 g=0.41，95%CI=0.09，0.72），而瑜伽与大的治疗效果相关（g=1.06，95%CI=0.69，1.43）。这些改善的组间差异具有统计学意义，瑜伽组优于常规护理组（B=-2.15，95%CI=-4.16，-0.15，p=0.035），但瑜伽组与有氧运动组之间无显著差异。未报告受伤情况。
研究结果支持推荐瑜伽作为未经治疗的 AUD 成人的治疗方法。
