Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Environ Pollut. 2022 Oct 15;311:120002. doi: 10.1016/j.envpol.2022.120002. Epub 2022 Aug 19.
Long-term noise exposure is reported to damage cardiovascular system, but the relationship between occupational noise exposure and arterial stiffness (AS) and the underlying mechanism is still unclear. We aimed to investigate the association of occupational noise exposure with arterial stiffness (AS), and further explore the mediation roles of microRNAs (miRNAs). A total of 838 workers were recruited from two companies in Wuhan, Hubei, China. Cumulative occupational noise exposure (CNE) was assessed through noise level of job title and work years in occupational noise. The AS for the participants were evaluated using brachial-ankle pulse wave velocity (baPWV) measured by an oscillometric device. Each 1-unit increase in CNE levels was significantly associated with a 0.002 (95% confidence interval (CI) = 0.001-0.003) unit increase in ln-transformed values of baPWV. In the sex-specific analysis, the association was significant in males (β = 0.002, 95%CI = 0.001-0.003). Meanwhile, the risk of bilateral hearing loss at high frequency was significantly higher in the high-exposed group than non-exposed group (OR = 1.895, 95%CI = 1.024-3.508), and participants with bilateral hearing loss at high frequency had a significantly higher level of ln-transformed baPWV (β = 0.032, 95%CI = 0.003-0.061). Occupational noise exposure and AS were both negatively associated with plasma miR-92a-3p and miR-21-5p, and the two miRNAs mediated 15.0% and 16.8% of the association of occupational noise with AS (P < 0.05). Our findings suggest that occupational noise exposure is positively associated with AS, and plasma miR-92a-3p and miR-21-5p may partly mediate such association.
长期噪声暴露据报道会损害心血管系统，但职业噪声暴露与动脉僵硬（AS）的关系及其潜在机制仍不清楚。我们旨在研究职业噪声暴露与动脉僵硬（AS）的关系，并进一步探讨 microRNAs（miRNAs）的中介作用。总共招募了 838 名来自中国湖北武汉两家公司的工人。通过职业噪声的职位噪声水平和工作年限评估累积职业噪声暴露（CNE）。使用示波法设备测量肱踝脉搏波速度（baPWV）评估参与者的 AS。CNE 水平每增加 1 个单位，ln 转换后的 baPWV 值就会显著增加 0.002（95%置信区间（CI）=0.001-0.003）个单位。在性别特异性分析中，男性的关联具有统计学意义（β=0.002，95%CI=0.001-0.003）。同时，高频双耳听力损失的高暴露组比非暴露组的风险显著更高（OR=1.895，95%CI=1.024-3.508），高频双耳听力损失的参与者的 ln 转换的 baPWV 值显著更高（β=0.032，95%CI=0.003-0.061）。职业噪声暴露和 AS 均与血浆 miR-92a-3p 和 miR-21-5p 呈负相关，并且这两个 miRNA 介导了职业噪声与 AS 关联的 15.0%和 16.8%（P<0.05）。我们的研究结果表明，职业噪声暴露与 AS 呈正相关，血浆 miR-92a-3p 和 miR-21-5p 可能部分介导了这种关联。
