Chen Z, Zhang H, Huang X, Tao Y, Chen Z, Sun X, Zhang M, Tse L A, Weng S, Chen W, Li W, Wang D
Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
J Endocrinol Invest. 2025 Jan;48(1):245-255. doi: 10.1007/s40618-024-02420-4. Epub 2024 Jun 23.
Noise exposure in the workplace has been linked to a number of health consequences. Our objectives were to explore the relationship between occupational noise and lipid metabolism and evaluate the possible mediating effect of obesity indices in those relationships with a cross-sectional study design.
Cumulative noise exposure (CNE) was used to measure the level of noise exposure. Logistic regression models or generalized linear models were employed to evaluate the association of occupational noise and obesity with lipid metabolism markers. Cross-lagged analysis was conducted to explore temporal associations of obesity with lipid metabolism.
A total of 854 participants were included, with each one-unit increase in CNE, the values of total cholesterol/high-density lipoprotein cholesterol and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol increased by 0.013 (95% confidence interval: 0.006, 0.020) and 0.009 (0.004, 0.014), as well as the prevalence of dyslipidemia increased by 1.030 (1.013, 1.048). Occupational noise and lipid metabolism markers were all positively associated with body mass index (BMI), waist circumference (WC), a Body Shape Index (ABSI) and a Body Shape Index and Body Roundness Index (BRI) (all P < 0.05). Moreover, BMI, WC, ABSI and BRI could mediate the associations of occupational noise with lipid metabolism; the proportions ranged from 21.51 to 24.45%, 23.84 to 30.14%, 4.86 to 5.94% and 25.59 to 28.23%, respectively (all P < 0.05).
Our study demonstrates a positive association between occupational noise and abnormal lipid metabolism, and obesity may partly mediate the association. Our findings reinforce the need to take practical steps to reduce or even eliminate the health risks associated with occupational noise.
工作场所的噪声暴露与多种健康后果相关。我们的目标是通过横断面研究设计，探讨职业噪声与脂质代谢之间的关系，并评估肥胖指标在这些关系中可能的中介作用。
采用累积噪声暴露（CNE）来衡量噪声暴露水平。使用逻辑回归模型或广义线性模型来评估职业噪声和肥胖与脂质代谢标志物之间的关联。进行交叉滞后分析以探讨肥胖与脂质代谢的时间关联。
共纳入854名参与者，CNE每增加一个单位，总胆固醇/高密度脂蛋白胆固醇和低密度脂蛋白胆固醇/高密度脂蛋白胆固醇的值分别增加0.013（95%置信区间：0.006，0.020）和0.009（0.004，0.014），血脂异常患病率增加1.030（1.013，1.048）。职业噪声和脂质代谢标志物均与体重指数（BMI）、腰围（WC）、体型指数（ABSI）以及体型指数和身体圆润度指数（BRI）呈正相关（均P<0.05）。此外，BMI、WC、ABSI和BRI可介导职业噪声与脂质代谢之间的关联；中介比例分别为21.51%至24.45%、23.84%至30.14%、4.86%至5.94%和25.59%至28.23%（均P<0.05）。
我们的研究表明职业噪声与脂质代谢异常之间存在正相关，肥胖可能部分介导了这种关联。我们的研究结果强化了采取实际措施减少甚至消除与职业噪声相关的健康风险的必要性。
