Mizuki Y, Hamasaki J, Hirano H, Miyoshi A, Yamada M, Inanaga K
Jpn J Psychiatry Neurol. 1986 Dec;40(4):647-53. doi: 10.1111/j.1440-1819.1986.tb03180.x.
The frontal midline theta activity which appears during a performance of mental tasks has been designated as Fm theta. Sixteen male university students who showed the appearance of Fm theta in 3 consecutive days were given 4 centrally acting drugs, i.e., diazepam 5 mg, amobarbital 80 mg, methylphenidate 15 mg and placebo, in a double-blind, crossover design. Scores were made on the state anxiety scale of Spielberger's State Trait Anxiety Inventory (STAI), and EEGs were recorded monopolarly before and during the performance of an arithmetic addition. The test was done twice, before and one hour after the drug administration. Placebo increased the appearance time of Fm theta, decreased the STAI scores and increased the tasks. Diazepam increased the appearance of Fm theta and decreased the state of anxiety but did not influence the amount of tasks. Amobarbital changed neither the appearance of Fm theta nor STAI scores but decreased the tasks slightly. Methylphenidate failed to influence the appearance of Fm theta but increased both the STAI scores and performed tasks. These results suggest that the appearance of Fm theta is influenced by the drugs and that the relief from anxiety might be involved in the appearance of Fm theta.
在执行心理任务期间出现的额中线θ活动被称为Fmθ。对连续三天出现Fmθ的16名男大学生，采用双盲交叉设计给予4种中枢作用药物，即地西泮5毫克、异戊巴比妥80毫克、哌甲酯15毫克和安慰剂。根据斯皮尔伯格状态特质焦虑量表（STAI）的状态焦虑量表进行评分，并在算术加法运算前和运算过程中进行单极脑电图记录。在给药前和给药后1小时进行了两次测试。安慰剂增加了Fmθ的出现时间，降低了STAI评分，并增加了任务量。地西泮增加了Fmθ的出现，并减轻了焦虑状态，但不影响任务量。异戊巴比妥既未改变Fmθ的出现情况，也未改变STAI评分，但略微减少了任务量。哌甲酯未能影响Fmθ的出现，但增加了STAI评分和完成的任务量。这些结果表明，Fmθ的出现受药物影响，焦虑缓解可能与Fmθ的出现有关。
