Mizuki Y, Hashimoto M, Tanaka T, Inanaga K, Tanaka M
Psychopharmacology (Berl). 1983;80(4):311-4. doi: 10.1007/BF00432111.
The theta activity which appears in the frontal midline area during performance of mental tasks has been designated as "Fm theta". In the present study, the possible use of zopiclone as an anxiolytic agent was investigated using Fm theta, in a comparison with diazepam. Sixteen male university students were given placebo, diazepam 5 mg, zopiclone 5 mg and 10 mg, in a double-blind, cross-over design. EEGs were recorded before and during performance of an arithmetic addition test. This test was repeated twice, prior to and 1 h following drug administration. Diazepam markedly increased Fm theta; however, both zopiclone 10 mg and placebo only slightly affected Fm theta, while zopiclone 5 mg failed to affect Fm theta. Scores of state anxiety were reduced markedly by diazepam and only slightly by zopiclone 10 mg, but were not affected by either zopiclone 5 mg or by placebo. Task performance was reduced markedly and in a dose-dependent manner by zopiclone, and very slightly by diazepam. These results suggest that zopiclone possesses a rather potent hypnotic effect, rather than an anxiolytic effect, and that Fm theta might be a useful tool in predicting the clinical efficacy of anxiolytic drugs in normal humans.
在执行心理任务期间出现在额中线区域的θ活动已被命名为“Fmθ”。在本研究中，使用Fmθ研究了佐匹克隆作为抗焦虑药物的可能性，并与地西泮进行了比较。16名男性大学生采用双盲、交叉设计，分别服用安慰剂、5毫克地西泮、5毫克和10毫克佐匹克隆。在进行算术加法测试之前和测试期间记录脑电图。该测试在给药前和给药后1小时重复进行两次。地西泮显著增加Fmθ；然而，10毫克佐匹克隆和安慰剂仅对Fmθ有轻微影响，而5毫克佐匹克隆对Fmθ没有影响。地西泮显著降低状态焦虑评分，10毫克佐匹克隆仅轻微降低，而5毫克佐匹克隆和安慰剂均未产生影响。佐匹克隆显著降低任务表现，且呈剂量依赖性，地西泮的影响非常轻微。这些结果表明，佐匹克隆具有相当强的催眠作用，而非抗焦虑作用，并且Fmθ可能是预测抗焦虑药物对正常人临床疗效的有用工具。
