Di Blasio Andrea, Di Dalmazi Giulia, Izzicupo Pascal, Bucci Ines, Giuliani Cesidio, Di Baldassarre Angela, Cecchi Francesca, Molino Lova Raffaele, Vannetti Federica, Napolitano Giorgio, Macchi Claudio
Department of Medicine and Aging Sciences, "G. D'Annunzio" University of Chieti-Pescara, Via L. Polacchi, 11, 66100 Chieti, Italy.
IRCCS Fondazione Don Carlo Gnocchi, Via di Scandicci, 269, 50143 Firenze, Italy.
J Funct Morphol Kinesiol. 2022 Aug 5;7(3):56. doi: 10.3390/jfmk7030056.
The current literature does not furnish clear data concerning the relationship between thyroid function, sedentary time and daily physical activity (PA) in older adults with euthyroid condition. The aim of this study was to investigate the association of serum Thyrotropin-Stimulating Hormone (TSH), free Triiodothyronine (fT3) and free Thyroxine (fT4) with sedentary time and PA in a cohort of nonagenarians.
A total of 108 nonagenarians (92.8 ± 3.2 years), participating in the Mugello Study, and with complete data on thyroid function, sedentary time, PA and sleeping (objectively collected through a multisensory device), were considered for the analysis.
Mainly, TSH negatively correlated with time spent lying down, and positively correlated with METs. fT4 levels were negatively associated with mean daily metabolic equivalents (METs) and with low-intensity PA practice (LIPAT), and positively associated with lying down and sleeping time. Similar results have been shown in the female sample. Mainly, participants with high-normal (third tertile) versus low-normal TSH (first tertile) had higher moderate-intensity PA (MIPAT) ( = 0.03). In the female sample, first TSH tertile had higher METs ( = 0.010), LIPAT ( = 0.02), MIPAT ( = 0.01) and lower time lying down ( = 0.04) than third TSH tertile.
High-normal serum TSH and low-normal fT4 are associated with higher levels and intensity of daily PA, together with higher MIPAT continuity, in the oldest-old.
目前的文献中没有提供关于甲状腺功能正常的老年人甲状腺功能、久坐时间和日常身体活动（PA）之间关系的确切数据。本研究的目的是调查一组九旬老人中血清促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（fT3）和游离甲状腺素（fT4）与久坐时间和PA之间的关联。
共有108名九旬老人（92.8±3.2岁）参与了穆杰罗研究，他们有关于甲状腺功能、久坐时间、PA和睡眠（通过多感官设备客观收集）的完整数据，被纳入分析。
主要发现，TSH与躺卧时间呈负相关，与代谢当量呈正相关。fT4水平与平均每日代谢当量（METs）和低强度PA练习（LIPAT）呈负相关，与躺卧和睡眠时间呈正相关。在女性样本中也得到了类似结果。主要是，TSH处于高正常范围（第三个三分位数）的参与者与低正常范围（第一个三分位数）的参与者相比，有更高的中等强度PA（MIPAT）（P = 0.03）。在女性样本中，TSH第一个三分位数的参与者比第三个三分位数的参与者有更高的METs（P = 0.010）、LIPAT（P = 0.02）、MIPAT（P = 0.01）和更低的躺卧时间（P = 0.04）。
在高龄老人中，血清TSH高正常范围和fT4低正常范围与更高水平和强度的日常PA以及更高的MIPAT连续性相关。
