美国成年人身体活动与甲状腺功能的关联：来自 NHANES 数据库的调查。
Association between physical activity and thyroid function in American adults: a survey from the NHANES database.
机构信息
Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155, Nanjing Bei Street, Shenyang, People's Republic of China.
Institute of endocrinology, The First Hospital of China Medical University, Shenyang, China.
出版信息
BMC Public Health. 2024 May 10;24(1):1277. doi: 10.1186/s12889-024-18768-4.
OBJECTIVE
Physical activity (PA) is closely related to our lives, and the effects of PA on thyroid function have not been elucidated.
METHODS
Using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2012, we included 5877 participants and analyzed the associations of thyroid function with weekly physical activity (PAM, expressed in metabolic equivalents of task) and physical activity time (PAT) in American adults. Univariate and multivariate logistic analyses were used to demonstrate the associations of PAM and PAT with the primary outcome. Linear regression analysis was performed to determine the associations between thyroid biochemical indicators/diseases and PAM/PAT.
RESULTS
Our study revealed noticeable sex differences in daily PA among the participants. The odds ratio of the fourth versus the first quartile of PAM was 3.07 (confidence interval, CI [1.24, 7.58], p = 0.02) for overt hypothyroidism, 3.25 (CI [1.12, 9.45], p = 0.03) for subclinical hyperthyroidism in adult men. PAT in the range of 633-1520 min/week was found to be associated with the occurrence of subclinical hyperthyroidism [p < 0.001, OR (95% CI) = 5.89 (1.85, 18.80)], PAT of the range of > 1520 min/week was found to be associated with the occurrence of overt hypothyroidism [p < 0.001, OR (95% CI) = 8.70 (2.80, 27.07)] and autoimmune thyroiditis (AIT) [p = 0.03, OR (95% CI) = 1.42 (1.03, 1.97)] in adult men. When PAM < 5000 MET*minutes/week or PAT < 1000 min/week, RCS showed an L-shaped curve for TSH and an inverted U-shaped curve for FT4. The changes in FT3 and TT3 in men were linearly positively correlated with PAM and PAT, while TT4 is linearly negatively correlated.
CONCLUSION
The amount of daily physical activity of American adults is strongly associated with changes in thyroid function, including thyroid hormone levels and thyroid diseases. Thyroid hormone levels were varied to a certain extent with changes in PAM and PAT.
目的
体力活动与我们的生活息息相关，其对甲状腺功能的影响尚未阐明。
方法
利用 2007-2012 年全国健康和营养调查（NHANES）的数据，我们纳入了 5877 名参与者，并分析了美国成年人每周体力活动（以代谢当量表示）和体力活动时间与甲状腺功能之间的关系。采用单变量和多变量逻辑分析来显示 PAM 和 PAT 与主要结局之间的关联。采用线性回归分析来确定甲状腺生化指标/疾病与 PAM/PAT 之间的关系。
结果
本研究揭示了参与者中每日体力活动的显著性别差异。与第一四分位相比，第四四分位的男性体力活动代谢当量（PAM）比值为 3.07（置信区间，CI[1.24，7.58]，p=0.02），亚临床甲状腺功能亢进症比值为 3.25（CI[1.12，9.45]，p=0.03）。每周 633-1520 分钟的 PAT 与亚临床甲状腺功能亢进症的发生有关（p<0.001，OR（95%CI）=5.89（1.85，18.80）），每周>1520 分钟的 PAT 与显性甲状腺功能减退症（p<0.001，OR（95%CI）=8.70（2.80，27.07））和自身免疫性甲状腺炎（AIT）（p=0.03，OR（95%CI）=1.42（1.03，1.97））的发生有关。当 PAM<5000 MET*分钟/周或 PAT<1000 分钟/周时，RCS 显示 TSH 呈 L 形曲线，FT4 呈倒 U 形曲线。男性 FT3 和 TT3 的变化与 PAM 和 PAT 呈线性正相关，而 TT4 呈线性负相关。
结论
美国成年人的日常体力活动量与甲状腺功能的变化密切相关，包括甲状腺激素水平和甲状腺疾病。甲状腺激素水平随着 PAM 和 PAT 的变化而在一定程度上发生变化。
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