从戈壁阿魏中分离得到的倍半萜香豆素及其抗神经炎症活性。

Sesquiterpene coumarins isolated from Ferula bungeana and their anti-neuroinflammatory activities.

作者信息

Guo Tingting, Dang Wen, Zhou Yaping, Zhou Di, Meng Qingqi, Xu Libin, Chen Gang, Lin Bin, Qing Degang, Sun Yu, Hou Yue, Li Ning

机构信息

School of Traditional Chinese Materia Medica, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, China.

College of Life and Health Sciences, Northeastern University, Shenyang 110004, China; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, China.

出版信息

Bioorg Chem. 2022 Nov;128:106102. doi: 10.1016/j.bioorg.2022.106102. Epub 2022 Aug 18.

DOI:10.1016/j.bioorg.2022.106102

PMID:35998519

Abstract

This is the first study to profile natural sesquiterpene coumarins (SCs) in Ferula bungeana, a medicinal plant of the genus Ferula in China. Eight undescribed sesquiterpene coumarins (1-8), along with six known ones (9-14) were obtained from the whole plant of F. bungeana. These unreported SCs (1-8) enriched the structural diversity of natural SCs, especially these with the hydroxy or carbonyl group at C-7' and a hydroperoxy group at C-7' or C-8'. Compounds (9-14) were reported for the first time from this plant. The in vitro anti-neuroinflammatory activity assay showed that compounds 2 and 9 showed stronger inhibitory effect on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced BV-2 microglia, compared with positive control minocycline, and compounds 5 and 10 showed moderate inhibitory effects.

摘要

这是首次对中国阿魏属药用植物新疆阿魏中的天然倍半萜香豆素（SCs）进行分析的研究。从新疆阿魏全株中获得了8个未描述的倍半萜香豆素（1 - 8）以及6个已知的（9 - 14）。这些未报道的SCs（1 - 8）丰富了天然SCs的结构多样性，特别是那些在C - 7'位带有羟基或羰基以及在C - 7'或C - 8'位带有氢过氧基的化合物。化合物（9 - 14）首次从该植物中报道。体外抗神经炎症活性测定表明，与阳性对照米诺环素相比，化合物2和9对脂多糖（LPS）诱导的BV - 2小胶质细胞中一氧化氮（NO）的产生具有更强的抑制作用，化合物5和10表现出中等抑制作用。