Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Phytother Res. 2011 Mar;25(3):315-23. doi: 10.1002/ptr.3311. Epub 2010 Oct 28.
Extracts from different species of the genus Ferula (Apiaceae) have had various biomedical applications for many centuries. Many biological features of this genus such as cytotoxicity, antibacterial, antiviral, P-glycoprotein (P-gp) inhibitory and antiinflammatory activity have been attributed to sesquiterpene coumarins; structures containing a common coumarin group and a sesquiterpene moiety. This both highlights the importance of sesquiterpene coumarins as biologically active natural products and necessitates further studies on these compounds. Taking into account the versatile biological properties of compounds isolated from Ferula and the unprecedented interest in the application of natural products as a new generation of therapeutics, the present review will discuss reports on biological activities of sesquiterpene coumarins of the genus Ferula, from 1990 onwards.
不同种属的 Ferula（伞形科）提取物在几个世纪以来有着各种各样的生物医学应用。该属的许多生物特性，如细胞毒性、抗菌、抗病毒、P 糖蛋白（P-gp）抑制和抗炎活性，都归因于倍半萜香豆素；这些结构含有一个常见的香豆素基团和一个倍半萜部分。这既突出了倍半萜香豆素作为生物活性天然产物的重要性，也需要对这些化合物进行进一步的研究。考虑到从 Ferula 中分离得到的化合物的多种生物特性，以及将天然产物作为新一代治疗药物应用的前所未有的兴趣，本综述将讨论 1990 年以来有关 Ferula 属倍半萜香豆素的生物活性的报道。
