Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China.
Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education of China, Xi'an, 710061, China.
Anal Chim Acta. 2022 Sep 1;1224:340237. doi: 10.1016/j.aca.2022.340237. Epub 2022 Aug 6.
Visualization of the electrochemical reaction is essential for comprehensively understanding the electrochemical reaction mechanism and precisely characterizing dynamic electrochemical processes. Herein, we propose a simple device that combines light-addressable potentiometric sensor (LAPS) imaging and microelectrodes to serve as a general electroanalysis platform for the label-free sensing and imaging of electrochemical reactions. In this device, two microelectrodes are assembled on the LAPS chip. Electrochemical reactions occurring on the microelectrodes can be qualitatively and quantitatively observed and visualized using a LAPS chip that is sensitive to the reaction products. Validations were performed to monitor the effect of water electrolysis and potassium ferrocyanide oxidation surrounding the microelectrodes, respectively. We believe that this study will provide an excellent platform for the visualization and monitoring of electrochemical reactions and broaden the application scope of LAPS imaging to a general electroanalysis tool that is widely applicable in several fields.
可视化电化学反应对于全面理解电化学反应机制和精确描述动态电化学过程至关重要。在此，我们提出了一种简单的装置，将光寻址电位传感器 (LAPS) 成像和微电极结合在一起，作为用于电化学反应的无标记传感和成像的通用电分析平台。在该装置中，两个微电极被组装在 LAPS 芯片上。通过对 LAPS 芯片的使用，可以定性和定量地观察和可视化发生在微电极上的电化学反应，该 LAPS 芯片对反应产物敏感。分别进行了验证实验，以监测微电极周围水电解和铁氰化钾氧化的影响。我们相信，这项研究将为电化学反应的可视化和监测提供一个极好的平台，并将 LAPS 成像的应用范围扩展到适用于多个领域的通用电分析工具。
