Yoshinobu Tatsuo, Ikeda Rintaro, Miyamoto Ko-Ichiro
Department of Biomedical Engineering, Tohoku University, Sendai 980-8579, Japan.
Department of Electronic Engineering, Tohoku University, Sendai 980-8579, Japan.
Sensors (Basel). 2024 Aug 30;24(17):5666. doi: 10.3390/s24175666.
A light-addressable potentiometric sensor (LAPS) is a semiconductor-based sensor platform for sensing and imaging of various chemical species. Being a potentiometric sensor, no faradaic current flows through its sensing surface, and no electrochemical reaction takes place in the course of LAPS measurement. In this study, a four-electrode system is proposed, in which a LAPS is combined with the conventional three-electrode electrochemical system. A LAPS is included as the fourth electrode for potentiometric sensing and imaging of the target analyte in the course of an electrochemical reaction taking place on the surface of the working electrode. The integrated system will be useful for analyzing dynamic processes, where both the electrochemical process on the electrode surface and the ion distribution in the solution need to be simultaneously investigated. Different grounding modes of control circuits that can simultaneously conduct potentiostatic/galvanostatic polarization and LAPS measurement are designed, and their functionalities are tested. The interference between polarization and LAPS measurement will also be discussed.
光寻址电位传感器（LAPS）是一种基于半导体的传感器平台，用于各种化学物质的传感和成像。作为一种电位传感器，没有法拉第电流流过其传感表面，并且在LAPS测量过程中不发生电化学反应。在本研究中，提出了一种四电极系统，其中将LAPS与传统的三电极电化学系统相结合。在工作电极表面发生电化学反应的过程中，将LAPS作为第四电极用于目标分析物的电位传感和成像。该集成系统对于分析动态过程将是有用的，在这些动态过程中，需要同时研究电极表面的电化学过程和溶液中的离子分布。设计了能够同时进行恒电位/恒电流极化和LAPS测量的控制电路的不同接地模式，并测试了它们的功能。还将讨论极化和LAPS测量之间的干扰。
